{"id":"85b56f19-98bb-54c5-b197-748fe98b0613","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:comt-moderation","predicate":"context_dependent_observation","statement":"COMT Val158Met genotype modified waking-function responses to modafinil in a selected sleep-deprivation experiment, while recovery-sleep measures were not similarly modified.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"10272ed3-d551-57c1-991e-d0ba34fd2843","mechanism_event_label":"COMT Val158Met genotype modified waking-function responses to modafinil in a selected sleep-deprivation experiment, while recovery-sleep measures were not similarly modified.","subject":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"object":{"id":"4497a61f-f047-57b3-8842-8df0ce8d370f","slug":"cognitive-task-performance","display_name":"Cognitive task performance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"10272ed3-d551-57c1-991e-d0ba34fd2843","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:comt-moderation-event","event_type":"experimental_observation","label":"COMT Val158Met genotype modified waking-function responses to modafinil in a selected sleep-deprivation experiment, while recovery-sleep measures were not similarly modified.","description":"In a selected sleep-deprivation study, COMT Val158Met genotype modified modafinil's effects on waking functions, while recovery-sleep measures were not similarly modified. This is evidence for biological variation in a defined experiment, not a validated genotype-based prescribing rule or proof that IQ reveals a person's dopamine concentration. [Pharmacogenetic study](https://pubmed.ncbi.nlm.nih.gov/19037200/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"role":"tested factor","stoichiometry":null,"state_label":"Modafinil within COMT genotype strata","sequence_order":0,"notes":""},{"entity":{"id":"4497a61f-f047-57b3-8842-8df0ce8d370f","slug":"cognitive-task-performance","display_name":"Cognitive task performance","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"mixed","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract checked; full methods and figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Modafinil within COMT genotype strata\", \"comparator\": \"Control and alternate genotype strata\", \"endpoint\": \"COMT Val158Met genotype modified waking-function responses to modafinil in a selected sleep-deprivation experiment, while recovery-sleep measures were not similarly modified.\", \"effect_direction\": \"mixed\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Selected human genotype groups under sleep deprivation; not a validated genotype-based prescribing rule.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"COMT Val158Met genotype modified waking-function responses to modafinil in a selected sleep-deprivation experiment, while recovery-sleep measures were not similarly modified.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Pharmacogenetics of modafinil after sleep loss: catechol-O-methyltransferase genotype modulates waking functions but not recovery sleep. | 2009 | DOI 10.1038/clpt.2008.222 | PMID 19037200 | https://pubmed.ncbi.nlm.nih.gov/19037200/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 156-156; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ff352a92-9606-5c73-81b7-562d78ed414d","evidence_kind":"source_excerpt","locator":"Lines 156-156","start_line":156,"end_line":156,"excerpt":"In a selected sleep-deprivation study, COMT Val158Met genotype modified modafinil's effects on waking functions, while recovery-sleep measures were not similarly modified. 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