{"id":"851b4c19-396e-5fb3-afd9-861696d91151","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-tasl-irf5","predicate":"recruits","statement":"The conserved TASL pLxIS motif mediated recruitment and activation of IRF5 downstream of endolysosomal TLR7/8/9 stimulation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4f71f477-7352-54b6-a7d1-1dc289af4e7f","mechanism_event_label":"An adaptor connects the membrane-associated system to a transcription factor.","subject":{"id":"82eae972-7da8-5908-bfd7-1d3c73e869ec","slug":"tasl","display_name":"Human TLR adaptor interacting with SLC15A4 / TASL","entity_type_key":"protein"},"object":{"id":"0f2e1ba6-30ca-5b3f-9876-41572817fdd3","slug":"irf5","display_name":"Human interferon regulatory factor 5 / IRF5","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"4f71f477-7352-54b6-a7d1-1dc289af4e7f","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-tasl-irf5-event","event_type":"observed_relationship","label":"An adaptor connects the membrane-associated system to a transcription factor.","description":"The conserved TASL pLxIS motif mediated recruitment and activation of IRF5 downstream of endolysosomal TLR7/8/9 stimulation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"82eae972-7da8-5908-bfd7-1d3c73e869ec","slug":"tasl","display_name":"Human TLR adaptor interacting with SLC15A4 / TASL","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0f2e1ba6-30ca-5b3f-9876-41572817fdd3","slug":"irf5","display_name":"Human interferon regulatory factor 5 / IRF5","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"44374451-3436-5136-a8ae-5dcc6d8c353b","slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"eca38509-73b3-5fc5-be33-2fa6d60ed1bb","slug":"slc15a4","display_name":"Human peptide/histidine transporter PHT1 / SLC15A4","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human immune-cell mutagenesis and signaling experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A shared transporter node does not establish a nutritional intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Histidine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An adaptor connects the membrane-associated system to a transcription factor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32433612/ · DOI 10.1038/s41586-020-2282-0","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d71b66b1-4994-5693-9f0c-28b48db26353","evidence_kind":"source_excerpt","locator":"Lines 386-392","start_line":386,"end_line":392,"excerpt":"## histidine-tasl-irf5\nAn adaptor connects the membrane-associated system to a transcription factor.\nThe conserved TASL pLxIS motif mediated recruitment and activation of IRF5 downstream of endolysosomal TLR7/8/9 stimulation.\nModel: Human immune-cell mutagenesis and signaling experiments.\nLimitations: A shared transporter node does not establish a nutritional intervention.\nEvidence access: Primary full text\nTASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32433612/ · DOI 10.1038/s41586-020-2282-0","model_system":"Human immune-cell mutagenesis and signaling experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"ce59e6c9-1213-523b-9d0b-400b7a81cd1c","stable_key":"import-911fb3c7-8cc3-5667-b677-5682fab67648","title":"L-Histidine: supply, catabolism, histamine, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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