{"id":"850a6cea-62b6-5bc8-b8b0-ba744dfeb0f5","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-pde5","predicate":"attenuates","statement":"Overexpressed PDE5 attenuated the cGMP-dependent anticancer signal.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"1caf12f1-ec43-5672-8940-5783bf7fbee1","mechanism_event_label":"An enzyme that removes cGMP can limit the response.","subject":{"id":"0be8b435-6b8a-592c-bd4c-c0efd9481a97","slug":"pde5-family","display_name":"Phosphodiesterase 5 family","entity_type_key":"protein_family"},"object":{"id":"f6ec8fb4-ef33-5f3c-b126-22b8ef52cc4b","slug":"egcg-cancer-cell-apoptosis","display_name":"Apoptosis in specified EGCG cancer models","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1caf12f1-ec43-5672-8940-5783bf7fbee1","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-pde5-event","event_type":"observed_relationship","label":"An enzyme that removes cGMP can limit the response.","description":"Overexpressed PDE5 attenuated the cGMP-dependent anticancer signal.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0be8b435-6b8a-592c-bd4c-c0efd9481a97","slug":"pde5-family","display_name":"Phosphodiesterase 5 family","entity_type_key":"protein_family"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f6ec8fb4-ef33-5f3c-b126-22b8ef52cc4b","slug":"egcg-cancer-cell-apoptosis","display_name":"Apoptosis in specified EGCG cancer models","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6d2f509b-3a5b-5a38-b3e7-b148581edec9","slug":"cgmp","display_name":"Cyclic guanosine monophosphate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Cancer-cell experiments and mouse xenografts in the 2013 study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preclinical combination experiments; normal-cell selectivity in tested preparations is not universal safety.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An enzyme that removes cGMP can limit the response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23348740/ · DOI 10.1172/jci64768","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2a5d5805-d364-5709-9fd2-5ed588827ab4","evidence_kind":"source_excerpt","locator":"Lines 84-90","start_line":84,"end_line":90,"excerpt":"## egcg-pde5\nAn enzyme that removes cGMP can limit the response.\nOverexpressed PDE5 attenuated the cGMP-dependent anticancer signal.\nModel: Cancer-cell experiments and mouse xenografts in the 2013 study.\nLimitations: Preclinical combination experiments; normal-cell selectivity in tested preparations is not universal safety.\nEvidence access: primary abstract.\n67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23348740/ · DOI 10.1172/jci64768","model_system":"Cancer-cell experiments and mouse xenografts in the 2013 study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}