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topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens; Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Several components of the bone-building program changed together.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[va-lind2013] Vitamin a is a negative regulator of osteoblast mineralization (2013). https://pubmed.ncbi.nlm.nih.gov/24340023/ DOI: 10.1371/journal.pone.0082388","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Osteoblasts","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c7dce6af-b756-5043-84f0-210114c20b89","evidence_kind":"source_excerpt","locator":"Lines 1662-1672","start_line":1662,"end_line":1672,"excerpt":"### va-retinoic-acid-osteoblast-markers\nRA-treated osteoblasts had reduced alkaline phosphatase and osteocalcin, with lower RUNX2/SP7 protein and PHEX expression.\nCondition category: normal\nnutrient_topic: Vitamin A research collection; 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