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(2002). https://pubmed.ncbi.nlm.nih.gov/11988104/ DOI: 10.1042/bj3640301","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intracellular retention and export","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"93c4a4d2-367f-5a77-94f7-046094d398b5","evidence_kind":"source_excerpt","locator":"Lines 320-331","start_line":320,"end_line":331,"excerpt":"### sulforaphane-abcb1-efflux\nP-glycoprotein overexpression also implicated ABCB1 in export of intracellular sulforaphane/conjugate pools.\nCondition category: normal\nnutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The measured pool can be influenced by more than one transporter.\norganism: Human HL60 leukemia and 8226 myeloma cells\ntissue_or_cell_type: Intracellular retention and export\nexperimental_model: Transporter-overexpression and temperature/inhibitor experiments\nlimitations: Cancer-cell transport experiments; not a measured clinical drug interaction.\nexposure: Sulforaphane loading; ABCC1 or ABCB1 expression\nevidence_span: {\"source_cache\": \"artifacts/sulforaphane-research/11988104.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5759bc0af52a1e906602549a3920ebba5641d09b63cc87f0dc61ea8efcb724a9\", \"start_char\": 0, \"end_char\": 1567, \"text_sha256\": \"5759bc0af52a1e906602549a3920ebba5641d09b63cc87f0dc61ea8efcb724a9\"}\n[sulforaphane-p11988104] High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. 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