{"id":"84bd598d-3391-5162-804b-6b9c3fd09e81","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-pdt-singlet","predicate":"quenches","statement":"KI shortened singlet-oxygen lifetime; derived quenching rate was 1.1 × 10^6 M−1 s−1.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"eb9d7be1-de9a-5e87-bca3-5287f53586f1","mechanism_event_label":"Iodide intercepted singlet oxygen in the photochemical system.","subject":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"object":{"id":"ac4a9e3e-1454-5802-82a3-3b3b18afc417","slug":"singlet-oxygen","display_name":"Singlet molecular oxygen","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"eb9d7be1-de9a-5e87-bca3-5287f53586f1","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-pdt-singlet-event","event_type":"observed_relationship","label":"Iodide intercepted singlet oxygen in the photochemical system.","description":"KI shortened singlet-oxygen lifetime; derived quenching rate was 1.1 × 10^6 M−1 s−1.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ac4a9e3e-1454-5802-82a3-3b3b18afc417","slug":"singlet-oxygen","display_name":"Singlet molecular oxygen","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"dcc30c48-e49e-5684-b289-082ce74d06bd","slug":"rose-bengal","display_name":"Rose bengal","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Rose bengal plus 540-nm light; up to 100 mM KI; microbial assays and a mouse skin-abrasion model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Local photochemical system, not an effect of oral KI alone. Peroxyiodide intermediates were proposed, not directly established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Iodide intercepted singlet oxygen in the photochemical system.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Potassium Iodide Potentiates Antimicrobial Photodynamic Inactivation Mediated by Rose Bengal in In Vitro and In Vivo Studies. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28438946/ · DOI 10.1128/aac.00467-17","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"093633c7-308e-58cc-b330-4ea82759282e","evidence_kind":"source_excerpt","locator":"Lines 336-342","start_line":336,"end_line":342,"excerpt":"## ki-pdt-singlet\nIodide intercepted singlet oxygen in the photochemical system.\nKI shortened singlet-oxygen lifetime; derived quenching rate was 1.1 × 10^6 M−1 s−1.\nModel: Rose bengal plus 540-nm light; up to 100 mM KI; microbial assays and a mouse skin-abrasion model.\nLimitations: Local photochemical system, not an effect of oral KI alone. Peroxyiodide intermediates were proposed, not directly established.\nEvidence location: Full-text Figure 5\nPotassium Iodide Potentiates Antimicrobial Photodynamic Inactivation Mediated by Rose Bengal in In Vitro and In Vivo Studies. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28438946/ · DOI 10.1128/aac.00467-17","model_system":"Rose bengal plus 540-nm light; up to 100 mM KI; microbial assays and a mouse skin-abrasion model.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text.","file_path":"","sha256":"3ff9da818dd7a763a59c6abcff2eaee136d7f887a777034feaa5ba304a8fa6ce","revision_id":"53f2ae88-8a91-5326-ac49-3bb510ca78c3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}