{"id":"84b443c1-78ae-5030-8e37-1f79f631f956","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-rat-phosphorus-balance","predicate":"increases","statement":"The higher-boron diet increased apparent phosphorus balance in vitamin-D-deprived rats, with substantial variability.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"8c598dc8-0aa4-545a-83d4-c7360e5e115b","mechanism_event_label":"The animal experiment measured greater apparent retention of phosphorus under the higher-boron diet.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"d5095ff4-c78b-5b62-85e1-7f00e4ab69dd","slug":"apparent-phosphorus-balance","display_name":"Apparent phosphorus balance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8c598dc8-0aa4-545a-83d4-c7360e5e115b","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-rat-phosphorus-balance-event","event_type":"observed_intervention","label":"The animal experiment measured greater apparent retention of phosphorus under the higher-boron diet.","description":"The higher-boron diet increased apparent phosphorus balance in vitamin-D-deprived rats, with substantial variability.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d5095ff4-c78b-5b62-85e1-7f00e4ab69dd","slug":"apparent-phosphorus-balance","display_name":"Apparent phosphorus balance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/7889882.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f9da927645dac0989b9d9a3eda4ebacc69e7b1b0abdb411e0112b9b51a8b8f1a\", \"start_char\": 0, \"end_char\": 1082, \"text_sha256\": \"f9da927645dac0989b9d9a3eda4ebacc69e7b1b0abdb411e0112b9b51a8b8f1a\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Vitamin-D-deficient rat feeding experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Dietary boron 2.72 versus 0.16 ppm with vitamin D deprivation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Apparent balances were variable. Previous vitamin D stores were a proposed explanation of variability, not proof that boron inhibits a vitamin D enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The animal experiment measured greater apparent retention of phosphorus under the higher-boron diet.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p7889882] Effects of dietary boron in rats fed a vitamin D-deficient diet. (1994). https://pubmed.ncbi.nlm.nih.gov/7889882/ DOI: 10.1289/ehp.94102s755","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole-body apparent mineral balance","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"1a46820a-8eed-59bd-aae8-77877e3c24cc","evidence_kind":"source_excerpt","locator":"Lines 833-844","start_line":833,"end_line":844,"excerpt":"### boron-rat-phosphorus-balance\nThe higher-boron diet increased apparent phosphorus balance in vitamin-D-deprived rats, with substantial variability.\nCondition category: nutrient_deficiency\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The animal experiment measured greater apparent retention of phosphorus under the higher-boron diet.\norganism: Rat\ntissue_or_cell_type: Whole-body apparent mineral balance\nexperimental_model: Vitamin-D-deficient rat feeding experiment\nlimitations: Apparent balances were variable. Previous vitamin D stores were a proposed explanation of variability, not proof that boron inhibits a vitamin D enzyme.\nexposure: Dietary boron 2.72 versus 0.16 ppm with vitamin D deprivation\nevidence_span: {\"source_cache\": \"artifacts/boron-research/7889882.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f9da927645dac0989b9d9a3eda4ebacc69e7b1b0abdb411e0112b9b51a8b8f1a\", \"start_char\": 0, \"end_char\": 1082, \"text_sha256\": \"f9da927645dac0989b9d9a3eda4ebacc69e7b1b0abdb411e0112b9b51a8b8f1a\"}\n[boron-p7889882] Effects of dietary boron in rats fed a vitamin D-deficient diet. (1994). https://pubmed.ncbi.nlm.nih.gov/7889882/ DOI: 10.1289/ehp.94102s755","model_system":"Vitamin-D-deficient rat feeding experiment","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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