{"id":"84af574f-26fc-51ee-9af6-7e8afcc0b102","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:bacterial-cadb-exchange","predicate":"mediates","statement":"E. coli CadB couples lysine uptake to cadaverine export in the Cad acid-response system.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ec1b0566-b260-524b-92af-7e1b1866890b","mechanism_event_label":"Transport connects extracellular lysine with bacterial cadaverine release.","subject":{"id":"c51b4440-b366-5749-8ce6-f806054ddf7d","slug":"e-coli-cadb","display_name":"E. coli CadB","entity_type_key":"protein"},"object":{"id":"444e6f89-10a9-5aad-8064-6486c960c963","slug":"lysine-cadaverine-exchange","display_name":"Lysine/cadaverine membrane exchange","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ec1b0566-b260-524b-92af-7e1b1866890b","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:bacterial-cadb-exchange-event","event_type":"biochemical_relationship","label":"Transport connects extracellular lysine with bacterial cadaverine release.","description":"E. coli CadB couples lysine uptake to cadaverine export in the Cad acid-response system.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c51b4440-b366-5749-8ce6-f806054ddf7d","slug":"e-coli-cadb","display_name":"E. coli CadB","entity_type_key":"protein"},"role":"enzyme","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"444e6f89-10a9-5aad-8064-6486c960c963","slug":"lysine-cadaverine-exchange","display_name":"Lysine/cadaverine membrane exchange","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"role":"transported_substrate","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"082dc221-9d81-5de3-8b73-0508a2ce0859","slug":"cadaverine","display_name":"Cadaverine","entity_type_key":"small_molecule"},"role":"countertransported_product","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"E. coli cells and membrane vesicles expressing CadB; cadaverine uptake/excretion and lysine exchange assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Bacterial antiport, not the mammalian intestinal lysine transporter or a clinical dysbiosis claim.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Escherichia coli","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Transport connects extracellular lysine with bacterial cadaverine release.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cadb-2004] Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli (2004). https://pubmed.ncbi.nlm.nih.gov/14982633/ DOI: 10.1046/j.1365-2958.2003.03913.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Not specified as a whole tissue; see experimental model.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3e244198-1ace-5e5c-805a-b16f8bdb0127","evidence_kind":"source_excerpt","locator":"Lines 628-636","start_line":628,"end_line":636,"excerpt":"### bacterial-cadb-exchange\nE. coli CadB couples lysine uptake to cadaverine export in the Cad acid-response system.\nPlain language: Transport connects extracellular lysine with bacterial cadaverine release.\nCondition category: normal\norganism: Escherichia coli\ntissue_or_cell_type: Not specified as a whole tissue; see experimental model.\nexperimental_model: E. coli cells and membrane vesicles expressing CadB; cadaverine uptake/excretion and lysine exchange assays.\nlimitations: Bacterial antiport, not the mammalian intestinal lysine transporter or a clinical dysbiosis claim.\n[cadb-2004] Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli (2004). https://pubmed.ncbi.nlm.nih.gov/14982633/ DOI: 10.1046/j.1365-2958.2003.03913.x","model_system":"E. coli cells and membrane vesicles expressing CadB; cadaverine uptake/excretion and lysine exchange assays.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [cadb-2004] Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli (2004). https://pubmed.ncbi.nlm.nih.gov/14982633/ DOI: 10.1046/j.1365-2958.2003.03913.x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93998d47c21525409ba82f1c82ededf2893dff15fbe61c7deffc175b0e298e97","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}