{"id":"8467f80d-c690-5b6e-89d8-a6ecb08fab6f","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:endocrine-prolactin","predicate":"increases_in_recorded_experiment","statement":"Prolactin increased thymulin secretion in human/mouse TEC cultures and thymulin activity in mice.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"84115d61-82ce-546c-a3fe-5c4c6d53bf6f","mechanism_event_label":"Prolactin increased thymulin secretion in human/mouse TEC cultures and thymulin activity in mice.","subject":{"id":"da232e57-9493-5b81-8701-0faf4218db46","slug":"prolactin","display_name":"Prolactin","entity_type_key":"peptide"},"object":{"id":"23819462-9bdf-5856-beac-68b3dca9cf85","slug":"thymulin","display_name":"Thymulin","entity_type_key":"peptide"},"evidence_count":1,"mechanism_event":{"id":"84115d61-82ce-546c-a3fe-5c4c6d53bf6f","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:endocrine-prolactin-event","event_type":"experimental_observation","label":"Prolactin increased thymulin secretion in human/mouse TEC cultures and thymulin activity in mice.","description":"| Prolactin | Increased thymulin secretion in human/mouse TEC cultures. In mice, prolactin increased activity; bromocriptine lowered it, and concurrent prolactin restored it. This is an experimental hormone/drug interaction, not proof that every bromocriptine-treated person develops thymulin deficiency. [1989 study](https://pubmed.ncbi.nlm.nih.gov/2737149/) |","status":"provisional","compartment":null,"participants":[{"entity":{"id":"da232e57-9493-5b81-8701-0faf4218db46","slug":"prolactin","display_name":"Prolactin","entity_type_key":"peptide"},"role":"tested factor","stoichiometry":null,"state_label":"prolactin exposure","sequence_order":0,"notes":""},{"entity":{"id":"23819462-9bdf-5856-beac-68b3dca9cf85","slug":"thymulin","display_name":"Thymulin","entity_type_key":"peptide"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary bibliographic record and abstract checked; full methods/figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"prolactin exposure\", \"comparator\": \"Matched experimental control\", \"endpoint\": \"Prolactin increased thymulin secretion in human/mouse TEC cultures and thymulin activity in mice.\", \"effect_direction\": \"increase\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Preparations and species as specified in statement and source; no direct iodine/selenium cofactor requirement inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Prolactin increased thymulin secretion in human/mouse TEC cultures and thymulin activity in mice.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Neuroendocrine control of thymic hormonal production. I. Prolactin stimulates in vivo and in vitro the production of thymulin by human and murine thymic epithelial cells. | 1989 | DOI 10.1210/endo-125-1-3 | PMID 2737149 | https://pubmed.ncbi.nlm.nih.gov/2737149/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 92-92; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fb252990-13a1-5527-a31c-578ae5c77688","evidence_kind":"source_excerpt","locator":"Lines 92-92","start_line":92,"end_line":92,"excerpt":"| Prolactin | Increased thymulin secretion in human/mouse TEC cultures. In mice, prolactin increased activity; bromocriptine lowered it, and concurrent prolactin restored it. This is an experimental hormone/drug interaction, not proof that every bromocriptine-treated person develops thymulin deficiency. [1989 study](https://pubmed.ncbi.nlm.nih.gov/2737149/) |","model_system":"Preparations and species as specified in statement and source; no direct iodine/selenium cofactor requirement inferred.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e1871d49-9c6b-547b-a1bb-6e2b9270ca89","stable_key":"import-18100170-a014-51c3-adeb-9dab4162b8cc","title":"Thymulin: detailed mechanisms of action (reviewed 3 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. 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