{"id":"84679f8f-3b45-59a9-9cca-d021b57c8119","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-human-depletion-insulin","predicate":"supports","statement":"Experimental depletion lowered clamp insulin response by 26% and glucose disposal by 27.4%; estimated tissue insulin sensitivity was unchanged.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"53d75836-4d4b-53ec-9f8a-b906e5c206e9","mechanism_event_label":"Depletion impaired glucose handling alongside a smaller insulin response.","subject":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"object":{"id":"7c50efe8-650e-5145-81ef-1c430510a538","slug":"insulin-secretion","display_name":"Insulin secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"53d75836-4d4b-53ec-9f8a-b906e5c206e9","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-human-depletion-insulin-event","event_type":"biochemical_relationship","label":"Depletion impaired glucose handling alongside a smaller insulin response.","description":"Experimental depletion lowered clamp insulin response by 26% and glucose disposal by 27.4%; estimated tissue insulin sensitivity was unchanged.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"role":"clamp stimulus","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"measured response","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"535a6fa5-3862-53ab-b277-e9064685b2af","slug":"sodium-polystyrene-sulfonate","display_name":"Sodium polystyrene sulfonate","entity_type_key":"chemical_species"},"role":"cointervention","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"7c50efe8-650e-5145-81ef-1c430510a538","slug":"insulin-secretion","display_name":"Insulin secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Potassium depletion altered carbohydrate handling; the precise cellular link remains unmeasured.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"combination\": \"single\", \"comparator\": \"Before depletion in the reported clamp study\", \"conditions\": [{\"entity_slug\": \"potassium\", \"state\": \"Experimentally depleted\"}], \"effect_direction\": \"decrease\", \"endpoint\": \"Clamp insulin response\", \"intervention\": \"Experimental potassium depletion\"}","comparator":null,"unit":null,"notes":"Comparison extracted from the existing source-pinned Rowe 1980 claim (PMID 6991855); no new primary full-text access in this pass. The raw supports/positive relationship is retained independently.","entity":null},{"dimension":"experimental_model","value_text":"Seven healthy young men; 7-8 days, 40 mEq K/day diet plus 60 g/day sodium polystyrene sulfonate; 2-hour hyperglycemic clamp 125 mg/dL above baseline.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Seven men; diet-plus-resin exposure. No direct beta-cell channel measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Depletion impaired glucose handling alongside a smaller insulin response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[rowe-1980-depletion] Effect of experimental potassium deficiency on glucose and insulin metabolism (1980). https://www.sciencedirect.com/science/article/pii/0026049580900748 DOI: 10.1016/0026-0495(80)90074-8","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Systemic glucose/insulin response","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"c545e4fa-5a2d-567e-9a8b-aa82a950386d","evidence_kind":"source_excerpt","locator":"Lines 834-844","start_line":834,"end_line":844,"excerpt":"### k-human-depletion-insulin\nExperimental depletion lowered clamp insulin response by 26% and glucose disposal by 27.4%; estimated tissue insulin sensitivity was unchanged.\nCondition category: nutrient_deficiency\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Depletion impaired glucose handling alongside a smaller insulin response.\norganism: Human\ntissue_or_cell_type: Systemic glucose/insulin response\nexperimental_model: Seven healthy young men; 7-8 days, 40 mEq K/day diet plus 60 g/day sodium polystyrene sulfonate; 2-hour hyperglycemic clamp 125 mg/dL above baseline.\nlimitations: Seven men; diet-plus-resin exposure. No direct beta-cell channel measurement.\ncross_nutrient: Potassium depletion altered carbohydrate handling; the precise cellular link remains unmeasured.\n[rowe-1980-depletion] Effect of experimental potassium deficiency on glucose and insulin metabolism (1980). https://www.sciencedirect.com/science/article/pii/0026049580900748 DOI: 10.1016/0026-0495(80)90074-8","model_system":"Seven healthy young men; 7-8 days, 40 mEq K/day diet plus 60 g/day sodium polystyrene sulfonate; 2-hour hyperglycemic clamp 125 mg/dL above baseline.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [rowe-1980-depletion] Effect of experimental potassium deficiency on glucose and insulin metabolism (1980). https://www.sciencedirect.com/science/article/pii/0026049580900748 DOI: 10.1016/0026-0495(80)90074-8","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}