{"id":"84456322-0d61-5e4e-b497-c0a19481d4da","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-diarrhea-dose-vomiting","predicate":"lower_doses_reduced","statement":"Vomiting within 30 minutes occurred in 19.3%, 15.6% and 13.7% of children at 20, 10 and 5 mg respectively; relative risks versus 20 mg were 0.81 (97.5% CI .67–.96) and .71 (.59–.86).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"a2f4ff11-934f-581c-a9be-56779b22fd74","mechanism_event_label":"Lower doses caused less vomiting in this trial.","subject":{"id":"9f823444-e2dd-5e16-9440-1bf2f62e8bdf","slug":"zinc-sulfate","display_name":"Zinc sulfate","entity_type_key":"chemical_species"},"object":{"id":"738c332c-eef8-5841-99bd-abcded257b0d","slug":"post-dose-vomiting","display_name":"Vomiting after an administered dose","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a2f4ff11-934f-581c-a9be-56779b22fd74","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-diarrhea-dose-vomiting-event","event_type":"observed_intervention","label":"Lower doses caused less vomiting in this trial.","description":"Vomiting within 30 minutes occurred in 19.3%, 15.6% and 13.7% of children at 20, 10 and 5 mg respectively; relative risks versus 20 mg were 0.81 (97.5% CI .67–.96) and .71 (.59–.86).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9f823444-e2dd-5e16-9440-1bf2f62e8bdf","slug":"zinc-sulfate","display_name":"Zinc sulfate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"738c332c-eef8-5841-99bd-abcded257b0d","slug":"post-dose-vomiting","display_name":"Vomiting after an administered dose","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Zinc exposure and the specifically measured response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Indexed primary abstract; accessible manuscript Methods and Results also inspected.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-clinical-sources/dhingra2020.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"48deafc698125c49384f5678bf65f3af2a4fc3359510f29a9a94a6b4991ee03e\", \"utf8_bytes\": 2238}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind randomized multicenter noninferiority trial in 4500 children aged 6–59 months in India and Tanzania","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"5, 10 or 20 mg zinc/day using zinc sulfate for 14 days.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Active-dose comparisons without a placebo arm. Noninferiority depends on the prespecified margin; not proof that doses are identical. Historical regimens are not current dosing guidance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Lower doses caused less vomiting in this trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-clin-dhingra2020] Lower-Dose Zinc for Childhood Diarrhea - A Randomized, Multicenter Trial. (2020). https://pubmed.ncbi.nlm.nih.gov/32966722/ DOI: 10.1056/nejmoa1915905","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Acute diarrheal illness and vomiting","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"de4bcb2a-5259-5d3c-9947-8ea05a65fb19","evidence_kind":"source_excerpt","locator":"Lines 1528-1541","start_line":1528,"end_line":1541,"excerpt":"### zn-clin-diarrhea-dose-vomiting\nVomiting within 30 minutes occurred in 19.3%, 15.6% and 13.7% of children at 20, 10 and 5 mg respectively; relative risks versus 20 mg were 0.81 (97.5% CI .67–.96) and .71 (.59–.86).\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Lower doses caused less vomiting in this trial.\norganism: Homo sapiens\ntissue_or_cell_type: Acute diarrheal illness and vomiting\nexperimental_model: Double-blind randomized multicenter noninferiority trial in 4500 children aged 6–59 months in India and Tanzania\nlimitations: Active-dose comparisons without a placebo arm. Noninferiority depends on the prespecified margin; not proof that doses are identical. Historical regimens are not current dosing guidance.\nexposure: 5, 10 or 20 mg zinc/day using zinc sulfate for 14 days.\ncross_nutrient: Zinc exposure and the specifically measured response.\nevidence_location: Indexed primary abstract; accessible manuscript Methods and Results also inspected.\nevidence_span: {\"source_cache\": \"artifacts/zinc-clinical-sources/dhingra2020.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"48deafc698125c49384f5678bf65f3af2a4fc3359510f29a9a94a6b4991ee03e\", \"utf8_bytes\": 2238}\n[zn-clin-dhingra2020] Lower-Dose Zinc for Childhood Diarrhea - A Randomized, Multicenter Trial. (2020). https://pubmed.ncbi.nlm.nih.gov/32966722/ DOI: 10.1056/nejmoa1915905","model_system":"Double-blind randomized multicenter noninferiority trial in 4500 children aged 6–59 months in India and Tanzania","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-clin-dhingra2020] Lower-Dose Zinc for Childhood Diarrhea - A Randomized, Multicenter Trial. (2020). https://pubmed.ncbi.nlm.nih.gov/32966722/ DOI: 10.1056/nejmoa1915905","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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