{"id":"8444890e-0c6d-5c08-901c-1f6a7703f4bb","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:yeast-mrs2-deletion-rapid-influx","predicate":"reduces","statement":"Yeast mrs2 deletion abolished the rapid mitochondrial Mg influx component while slow residual accumulation remained.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"4cd1dc24-a4c3-5282-833d-12cde3498c02","mechanism_event_label":"The yeast channel is required for rapid magnesium entry into mitochondria.","subject":{"id":"d74df163-4b67-5d93-b9c6-912b6440bdaa","slug":"yeast-mrs2-null-genotype","display_name":"Yeast mrs2 deletion genotype","entity_type_key":"gene"},"object":{"id":"b47df614-7498-5a76-85cf-b7ffbdb970d9","slug":"mitochondrial-magnesium-uptake","display_name":"Mitochondrial magnesium uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4cd1dc24-a4c3-5282-833d-12cde3498c02","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:yeast-mrs2-deletion-rapid-influx-event","event_type":"biochemical_relationship","label":"The yeast channel is required for rapid magnesium entry into mitochondria.","description":"Yeast mrs2 deletion abolished the rapid mitochondrial Mg influx component while slow residual accumulation remained.","status":"provisional","compartment":{"slug":"inner-mitochondrial-membrane","display_name":"Inner mitochondrial membrane"},"participants":[{"entity":{"id":"1d659161-1f70-5620-9f87-26f30516f268","slug":"yeast-mrs2p","display_name":"Saccharomyces cerevisiae Mrs2p","entity_type_key":"protein"},"role":"deleted-protein","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"transported-ion","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d74df163-4b67-5d93-b9c6-912b6440bdaa","slug":"yeast-mrs2-null-genotype","display_name":"Yeast mrs2 deletion genotype","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b47df614-7498-5a76-85cf-b7ffbdb970d9","slug":"mitochondrial-magnesium-uptake","display_name":"Mitochondrial magnesium uptake","entity_type_key":"cellular_process"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [kolisek-2003-mrs2] Mrs2p is an essential component of the major electrophoretic Mg2+ influx system in mitochondria (2003). https://pmc.ncbi.nlm.nih.gov/articles/PMC151051/ DOI: 10.1093/emboj/cdg122","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}