{"id":"84130391-7880-59a9-9c19-d4b6aeb522a6","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-hydration","predicate":"hydrates_to","statement":"The aqueous 6-gingerol/6-shogaol system also supported the reverse hydration reaction.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"397b695c-930f-58d7-a780-d248e709658c","mechanism_event_label":"The aqueous 6-gingerol/6-shogaol system also supported the reverse hydration reaction.","subject":{"id":"ff5f7b6c-070c-52e9-898d-0ce17a5a59db","slug":"6-shogaol","display_name":"6-Shogaol","entity_type_key":"small_molecule"},"object":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"397b695c-930f-58d7-a780-d248e709658c","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-hydration-event","event_type":"observed_relationship","label":"The aqueous 6-gingerol/6-shogaol system also supported the reverse hydration reaction.","description":"The aqueous 6-gingerol/6-shogaol system also supported the reverse hydration reaction.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ff5f7b6c-070c-52e9-898d-0ce17a5a59db","slug":"6-shogaol","display_name":"6-Shogaol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"6-Gingerol; 37-100 degrees C, pH 1, 4 or 7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Kinetic measurements; equilibrium within 2 h at 100 degrees C and pH 1","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free aqueous solution","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Processing chemistry is not proof of conversion after human ingestion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Cell-free aqueous solution","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The aqueous 6-gingerol/6-shogaol system also supported the reverse hydration reaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The stability of gingerol and shogaol in aqueous solutions. (2001). https://pubmed.ncbi.nlm.nih.gov/11745724/ DOI: 10.1002/jps.1116","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro chemical incubation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Aqueous chemical preparation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"27e750f6-4992-5979-bbf1-8f01ca12cb8b","evidence_kind":"source_excerpt","locator":"Lines 30-39","start_line":30,"end_line":39,"excerpt":"## gingerols-6-hydration\nThe aqueous 6-gingerol/6-shogaol system also supported the reverse hydration reaction.\nModel/species: Cell-free aqueous solution\nTissue: Aqueous chemical preparation\nExposure: 6-Gingerol; 37-100 degrees C, pH 1, 4 or 7\nRoute: In vitro chemical incubation\nDuration: Kinetic measurements; equilibrium within 2 h at 100 degrees C and pH 1\nLimits: Processing chemistry is not proof of conversion after human ingestion.\nPrimary reference: The stability of gingerol and shogaol in aqueous solutions. (2001). https://pubmed.ncbi.nlm.nih.gov/11745724/ DOI: 10.1002/jps.1116\nAccess: Primary PubMed abstract.","model_system":"Cell-free aqueous solution","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived synthesis span with its primary citation; original paraphrase, not a claimed publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1107d60b-8e2d-55d7-8f5d-5612c49aa7dc","stable_key":"import-fd7915ff-856d-56c2-a118-4989693a7644","title":"Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. 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