{"id":"84058d06-4cfe-557d-8411-252577c3775b","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-sulfite-network-dose","predicate":"high_exposure_induces","statement":"Moderate sulfite elevation promoted interconnected networks, whereas high sulfite induced fragmentation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b1c1925a-ec61-5afb-8579-159d0fc21dd5","mechanism_event_label":"The same substance produced different mitochondrial patterns at different concentrations.","subject":{"id":"914ace7c-9176-53f7-80a9-9ee71d26ea52","slug":"sulfite","display_name":"Sulfite / SO3(2-)","entity_type_key":"ion"},"object":{"id":"9aa292e6-9c25-5174-ac06-6c990f604ad2","slug":"mitochondrial-network-fragmentation","display_name":"Mitochondrial network fragmentation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b1c1925a-ec61-5afb-8579-159d0fc21dd5","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-sulfite-network-dose-event","event_type":"biochemical_relationship","label":"The same substance produced different mitochondrial patterns at different concentrations.","description":"Moderate sulfite elevation promoted interconnected networks, whereas high sulfite induced fragmentation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"914ace7c-9176-53f7-80a9-9ee71d26ea52","slug":"sulfite","display_name":"Sulfite / SO3(2-)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9aa292e6-9c25-5174-ac06-6c990f604ad2","slug":"mitochondrial-network-fragmentation","display_name":"Mitochondrial network fragmentation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/molybdenum-research/33488670.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4cd0f95e723b56151456d582ec34bc7cd57c8e4a3d7e424b1d043a9cd5cfa962\", \"start_char\": 0, \"end_char\": 1946, \"text_sha256\": \"4cd0f95e723b56151456d582ec34bc7cd57c8e4a3d7e424b1d043a9cd5cfa962\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"SO-deficient mouse embryonic fibroblasts, sulfite titration and MoCD patient fibroblasts","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Galactose culture and graded sulfite exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Network architecture is concentration dependent; fibroblast findings are not a direct human brain measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Molybdenum research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus and Homo sapiens in distinct experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The same substance produced different mitochondrial patterns at different concentrations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mo-p33488670] Sulfite Alters the Mitochondrial Network in Molybdenum Cofactor Deficiency. 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