{"id":"83f5413c-d517-519c-9847-79fcc1ef4ca1","stable_key":"56f1d914-e7da-595a-af69-c217b2b47407:l-phenylalanine-pagln-outcomes","predicate":"is_associated_with","statement":"Circulating PAGln was associated with cardiovascular disease and subsequent major adverse cardiovascular events in discovery and validation cohorts of 1162 and 4000 subjects.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f3d54f2c-c774-5fde-870a-784f79db787a","mechanism_event_label":"A blood association identifies a research signal, not the cause by itself.","subject":{"id":"8968a92b-40e9-56fe-8d76-d8776750dbd6","slug":"phenylacetylglutamine","display_name":"Phenylacetylglutamine / PAGln","entity_type_key":"small_molecule"},"object":{"id":"f903ffc5-9611-5615-a9ac-92e945a6c108","slug":"human-pagln-cardiovascular-events","display_name":"Cardiovascular events associated with circulating PAGln","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f3d54f2c-c774-5fde-870a-784f79db787a","stable_key":"56f1d914-e7da-595a-af69-c217b2b47407:l-phenylalanine-pagln-outcomes-event","event_type":"observed_relationship","label":"A blood association identifies a research signal, not the cause by itself.","description":"Circulating PAGln was associated with cardiovascular disease and subsequent major adverse cardiovascular events in discovery and validation cohorts of 1162 and 4000 subjects.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8968a92b-40e9-56fe-8d76-d8776750dbd6","slug":"phenylacetylglutamine","display_name":"Phenylacetylglutamine / PAGln","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f903ffc5-9611-5615-a9ac-92e945a6c108","slug":"human-pagln-cardiovascular-events","display_name":"Cardiovascular events associated with circulating PAGln","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"190407ad-0219-54b5-b05f-7c75f3895ca6","slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human clinical cohorts; three-year event follow-up.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Residual confounding and renal clearance matter; no randomized dietary phenylalanine intervention establishes causation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Phenylalanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A blood association identifies a research signal, not the cause by itself.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32142679/ · DOI 10.1016/j.cell.2020.02.016","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"05b3ca90-4c26-5f2c-96b8-a9a331f6a3a8","evidence_kind":"source_excerpt","locator":"Lines 390-396","start_line":390,"end_line":396,"excerpt":"## l-phenylalanine-pagln-outcomes\nA blood association identifies a research signal, not the cause by itself.\nCirculating PAGln was associated with cardiovascular disease and subsequent major adverse cardiovascular events in discovery and validation cohorts of 1162 and 4000 subjects.\nModel: Human clinical cohorts; three-year event follow-up.\nLimitations: Residual confounding and renal clearance matter; no randomized dietary phenylalanine intervention establishes causation.\nEvidence access: Primary full text\nA Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32142679/ · DOI 10.1016/j.cell.2020.02.016","model_system":"Human clinical cohorts; three-year event follow-up.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54de7c56-1e60-5d7b-8ef9-852c58ae92ba","stable_key":"import-56f1d914-e7da-595a-af69-c217b2b47407","title":"L-Phenylalanine: transport, protein synthesis, cofactor recycling and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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