{"id":"83e99e6d-b774-5d27-ba71-04b638ff0252","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-depletion-human-pressure","predicate":"depletion_increases","statement":"Low potassium increased systolic/diastolic pressure by about 7/6 mmHg in the same crossover.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"5f4c80a5-5d0e-5ed2-ab6e-dfaa155e3555","mechanism_event_label":"In this setting, lowering potassium raised blood pressure.","subject":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"object":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5f4c80a5-5d0e-5ed2-ab6e-dfaa155e3555","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-depletion-human-pressure-event","event_type":"observed_intervention","label":"In this setting, lowering potassium raised blood pressure.","description":"Low potassium increased systolic/diastolic pressure by about 7/6 mmHg in the same crossover.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"controlled_intake","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Potassium/sodium balance -> pressure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same cohort and intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not an independent replication or proof of one molecular mediator.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In this setting, lowering potassium raised blood pressure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k-krishna1991] Potassium depletion exacerbates essential hypertension (1991). https://pubmed.ncbi.nlm.nih.gov/2058867/ DOI: 10.7326/0003-4819-115-2-77","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Systemic circulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"07e27a01-d546-59df-97b7-8ffaa6f53f05","evidence_kind":"source_excerpt","locator":"Lines 1522-1532","start_line":1522,"end_line":1532,"excerpt":"### k-depletion-human-pressure\nLow potassium increased systolic/diastolic pressure by about 7/6 mmHg in the same crossover.\nCondition category: nutrient_deficiency\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: In this setting, lowering potassium raised blood pressure.\norganism: Homo sapiens\ntissue_or_cell_type: Systemic circulation\nexperimental_model: Same cohort and intervention.\nlimitations: Not an independent replication or proof of one molecular mediator.\ncross_nutrient: Potassium/sodium balance -> pressure.\n[k-krishna1991] Potassium depletion exacerbates essential hypertension (1991). https://pubmed.ncbi.nlm.nih.gov/2058867/ DOI: 10.7326/0003-4819-115-2-77","model_system":"Same cohort and intervention.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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