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Cross-nutrient implications identify pathway dependence rather than a proven supplement response.\nexposure: Genetic deletion of hepatic pyruvate carboxylase\nevidence_span: {\"source_cache\": \"artifacts/biotin-research/31006591.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0dcedbfac623863bd4ae86ed1bb97cef0ef56bd417bd0d49507ef47d16af7b4e\", \"start_char\": 0, \"end_char\": 1141, \"text_sha256\": \"0dcedbfac623863bd4ae86ed1bb97cef0ef56bd417bd0d49507ef47d16af7b4e\"}\n[b7-p31006591] Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver. (2019). https://pubmed.ncbi.nlm.nih.gov/31006591/ DOI: 10.1016/j.cmet.2019.03.014","model_system":"Liver-specific Pcx-knockout mice","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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