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Transplantation between rats supports the microbial step; human relevance is not established here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Metformin research collection; topical membership is not evidence of a direct clinical effect, and pharmacological exposure is not dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"metformin","display_name":"Metformin","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A sensor in the upper gut tells the liver to make less glucose, and the drug restores it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[metformin-p29056513] Metformin Alters Upper Small Intestinal Microbiota that Impact a Glucose-SGLT1-Sensing Glucoregulatory Pathway. 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Transplantation between rats supports the microbial step; human relevance is not established here.\nexposure: Upper small-intestinal metformin in high-fat-diet rats\nevidence_span: {\"source_cache\": \"artifacts/metformin-research/29056513.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a04767b5cd42e2e3e3eced3fc1f6bc2c20d8c71adb044483fe8443ef1c59fc97\", \"start_char\": 0, \"end_char\": 1110, \"text_sha256\": \"a04767b5cd42e2e3e3eced3fc1f6bc2c20d8c71adb044483fe8443ef1c59fc97\"}\n[metformin-p29056513] Metformin Alters Upper Small Intestinal Microbiota that Impact a Glucose-SGLT1-Sensing Glucoregulatory Pathway. 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