{"id":"832fff05-0c15-53e1-afb6-bdd9d0f112a9","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-mtap-salvage","predicate":"clears","statement":"MTAP loss caused methylthioadenosine accumulation in the study cancer-cell systems, identifying salvage failure as a change in the intracellular metabolite environment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"085cf489-22fd-5d1e-acc5-e7e60f281164","mechanism_event_label":"A product of polyamine synthesis must be recycled or removed.","subject":{"id":"fcd3b947-abdf-5e52-904f-a24f475e446c","slug":"mtap","display_name":"Human methylthioadenosine phosphorylase / MTAP","entity_type_key":"protein"},"object":{"id":"525860da-a986-5d19-97f0-a257a454b649","slug":"5-methylthioadenosine","display_name":"5′-Methylthioadenosine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"085cf489-22fd-5d1e-acc5-e7e60f281164","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-mtap-salvage-event","event_type":"observed_relationship","label":"A product of polyamine synthesis must be recycled or removed.","description":"MTAP loss caused methylthioadenosine accumulation in the study cancer-cell systems, identifying salvage failure as a change in the intracellular metabolite environment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fcd3b947-abdf-5e52-904f-a24f475e446c","slug":"mtap","display_name":"Human methylthioadenosine phosphorylase / MTAP","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"525860da-a986-5d19-97f0-a257a454b649","slug":"5-methylthioadenosine","display_name":"5′-Methylthioadenosine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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