{"id":"8325e0b8-c436-5902-8eed-6ba19a34af6d","stable_key":"e69ef6a0-0e23-5eac-aca1-cf333781b962:ino-ip6k1-insulin","predicate":"loss_increases","statement":"Ip6k1-null mice showed increased insulin sensitivity and resistance to diet- or age-associated obesity.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"9d6da4c4-caaa-5839-aa0b-e1599805c5b5","mechanism_event_label":"Removing a specific signaling enzyme improved these metabolic outcomes in mice.","subject":{"id":"8d5467e4-21ad-57a2-97cd-9c783ef035bf","slug":"mouse-ip6k1","display_name":"Mouse Ip6k1","entity_type_key":"protein"},"object":{"id":"6bb58c9a-8bd2-560e-a11b-ecf2935dd333","slug":"insulin-sensitivity","display_name":"Insulin sensitivity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9d6da4c4-caaa-5839-aa0b-e1599805c5b5","stable_key":"e69ef6a0-0e23-5eac-aca1-cf333781b962:ino-ip6k1-insulin-event","event_type":"biochemical_relationship","label":"Removing a specific signaling enzyme improved these metabolic outcomes in mice.","description":"Ip6k1-null mice showed increased insulin sensitivity and resistance to diet- or age-associated obesity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8d5467e4-21ad-57a2-97cd-9c783ef035bf","slug":"mouse-ip6k1","display_name":"Mouse Ip6k1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6bb58c9a-8bd2-560e-a11b-ecf2935dd333","slug":"insulin-sensitivity","display_name":"Insulin sensitivity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/inositol-research/21145457.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0de0a9c3ea11cd8ce59bccff69a41139b11e11182fd9fd66016ec72ba329a5ce\", \"start_char\": 0, \"end_char\": 889, \"text_sha256\": \"0de0a9c3ea11cd8ce59bccff69a41139b11e11182fd9fd66016ec72ba329a5ce\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Biochemical Akt regulation and targeted mouse Ip6k1 deletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"5-InsP7 and Ip6k1 knockout","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Whole-gene deletion is not equivalent to adding or withdrawing free myo-inositol; the reported therapeutic proposal is not established treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Inositol research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"inositol","display_name":"Inositol (stereoisomer family)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mammalian enzymology and Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Removing a specific signaling enzyme improved these metabolic outcomes in mice.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ino-p21145457] Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. (2010). https://pubmed.ncbi.nlm.nih.gov/21145457/ DOI: 10.1016/j.cell.2010.11.032","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Muscle, adipose tissue and liver","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"1a43608b-e547-58e6-8575-f7ce9c1fb9f3","evidence_kind":"source_excerpt","locator":"Lines 795-806","start_line":795,"end_line":806,"excerpt":"### ino-ip6k1-insulin\nIp6k1-null mice showed increased insulin sensitivity and resistance to diet- or age-associated obesity.\nCondition category: machinery_impairment\nnutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Removing a specific signaling enzyme improved these metabolic outcomes in mice.\norganism: Mammalian enzymology and Mus musculus\ntissue_or_cell_type: Muscle, adipose tissue and liver\nexperimental_model: Biochemical Akt regulation and targeted mouse Ip6k1 deletion\nlimitations: Whole-gene deletion is not equivalent to adding or withdrawing free myo-inositol; the reported therapeutic proposal is not established treatment.\nexposure: 5-InsP7 and Ip6k1 knockout\nevidence_span: {\"source_cache\": \"artifacts/inositol-research/21145457.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0de0a9c3ea11cd8ce59bccff69a41139b11e11182fd9fd66016ec72ba329a5ce\", \"start_char\": 0, \"end_char\": 889, \"text_sha256\": \"0de0a9c3ea11cd8ce59bccff69a41139b11e11182fd9fd66016ec72ba329a5ce\"}\n[ino-p21145457] Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. (2010). https://pubmed.ncbi.nlm.nih.gov/21145457/ DOI: 10.1016/j.cell.2010.11.032","model_system":"Biochemical Akt regulation and targeted mouse Ip6k1 deletion","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ino-p21145457] Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. (2010). https://pubmed.ncbi.nlm.nih.gov/21145457/ DOI: 10.1016/j.cell.2010.11.032","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d590c659-b774-50e6-9f1d-aff61d5f7c9c","stable_key":"import-e69ef6a0-0e23-5eac-aca1-cf333781b962","title":"Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f7adbcedad647d5f8a3cc9e46bfa515e83c508be9c2a4e9d59c5f5dfb0667d53","revision_id":"a82d187c-60fb-52d1-8482-eadb92860f33","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}