{"id":"82f64481-40d4-5eb8-9c33-92e910c54099","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-glucose-use","predicate":"reduces","statement":"Glucose oxidation decreased approximately 85%.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"2da79a8c-3648-5cdf-9161-090e75ba657a","mechanism_event_label":"The body conserved glucose by burning less of it.","subject":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"object":{"id":"db490d09-4e4e-5f4f-9a19-33d37355e39c","slug":"whole-body-glucose-oxidation","display_name":"Whole-body glucose oxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2da79a8c-3648-5cdf-9161-090e75ba657a","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-glucose-use-event","event_type":"observed_relationship","label":"The body conserved glucose by burning less of it.","description":"Glucose oxidation decreased approximately 85%.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"db490d09-4e4e-5f4f-9a19-33d37355e39c","slug":"whole-body-glucose-oxidation","display_name":"Whole-body glucose oxidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six men; isotope tracers and indirect calorimetry during a 60-hour fast.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Protocol-specific fluxes; no universal hour-by-hour threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"The body conserved glucose by burning less of it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Fuel and energy metabolism in fasting humans. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8017334/ · DOI 10.1093/ajcn/60.1.29","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ba9bd886-76c5-5b08-9ec4-3d469957c437","evidence_kind":"source_excerpt","locator":"Lines 48-54","start_line":48,"end_line":54,"excerpt":"## fast-glucose-use\nThe body conserved glucose by burning less of it.\nGlucose oxidation decreased approximately 85%.\nModel: Six men; isotope tracers and indirect calorimetry during a 60-hour fast.\nLimitations: Protocol-specific fluxes; no universal hour-by-hour threshold.\nEvidence access: Primary abstract\nFuel and energy metabolism in fasting humans. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8017334/ · DOI 10.1093/ajcn/60.1.29","model_system":"Six men; isotope tracers and indirect calorimetry during a 60-hour fast.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}