{"id":"82da7944-a8c7-521e-878c-d482dee3c1d1","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-rat-hfcs-lipid","predicate":"increases","statement":"Rats drinking HFCS-55 had the highest hepatic triglyceride and total lipid content among the tested solutions.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"4be16194-f8e8-5854-b2b2-0c44f9b656e7","mechanism_event_label":"Rats drinking HFCS-55 had the highest hepatic triglyceride and total lipid content among the tested solutions.","subject":{"id":"9e77d6b7-d2b2-5fd5-a42a-6c4ff1885abf","slug":"hfcs-55","display_name":"HFCS-55","entity_type_key":"chemical_species"},"object":{"id":"e1856ab7-5c9b-59f1-8a99-5a20966ef466","slug":"rat-hepatic-triglyceride-content","display_name":"Rat hepatic triglyceride content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4be16194-f8e8-5854-b2b2-0c44f9b656e7","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-rat-hfcs-lipid-event","event_type":"observed_relationship","label":"Rats drinking HFCS-55 had the highest hepatic triglyceride and total lipid content among the tested solutions.","description":"Rats drinking HFCS-55 had the highest hepatic triglyceride and total lipid content among the tested solutions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9e77d6b7-d2b2-5fd5-a42a-6c4ff1885abf","slug":"hfcs-55","display_name":"HFCS-55","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e1856ab7-5c9b-59f1-8a99-5a20966ef466","slug":"rat-hepatic-triglyceride-content","display_name":"Rat hepatic triglyceride content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"832b1926-18e7-5b76-8dc4-bad8ed234645","slug":"high-fructose-corn-syrup","display_name":"High-Fructose Corn Syrup / HFCS","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"3c379840-5688-5b5d-84c0-5950b4fd8f17","slug":"fructose","display_name":"Fructose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"13% w/v HFCS-55, sucrose or fructose solution versus water","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"8 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract/metadata; unrecovered methods explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Female rats, seven per group","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Direct HFCS-55 animal evidence","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Hypercaloric animal setting. Expression and fatty-acid composition suggest lipogenesis but are not isotope flux measurements; differences do not establish HFCS superiority/inferiority in humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"high-fructose-corn-syrup","display_name":"High-Fructose Corn Syrup / HFCS","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Female rats, seven per group","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Rats drinking HFCS-55 had the highest hepatic triglyceride and total lipid content among the tested solutions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation. (2017). https://pubmed.ncbi.nlm.nih.gov/27768909/ DOI: 10.1016/j.jnutbio.2016.09.010","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral ad libitum solution","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Hepatic lipid and expression endpoints","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ef7749a0-283d-5f83-aab1-77ce5d3a900b","evidence_kind":"source_excerpt","locator":"Lines 425-435","start_line":425,"end_line":435,"excerpt":"## hfcs-rat-hfcs-lipid\nRats drinking HFCS-55 had the highest hepatic triglyceride and total lipid content among the tested solutions.\nModel/species: Female rats, seven per group\nTissue: Hepatic lipid and expression endpoints\nExposure: 13% w/v HFCS-55, sucrose or fructose solution versus water\nRoute: Oral ad libitum solution\nDuration: 8 weeks\nExposure scope: Direct HFCS-55 animal evidence\nLimits: Hypercaloric animal setting. Expression and fatty-acid composition suggest lipogenesis but are not isotope flux measurements; differences do not establish HFCS superiority/inferiority in humans.\nReference: High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation. (2017). https://pubmed.ncbi.nlm.nih.gov/27768909/ DOI: 10.1016/j.jnutbio.2016.09.010\nAccess: Primary abstract/metadata; unrecovered methods explicitly retained.","model_system":"Female rats, seven per group","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e863ddf6-7c1e-5a70-8335-7f3ac3eeee92","stable_key":"import-c8c7aa13-14c6-5f5c-9afc-9217d0f2f736","title":"High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. 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