{"id":"82996083-8767-54dd-ac73-c8b2c9d15907","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-retest-inconsistency","predicate":"has_inconsistent_retested_association_with","statement":"Repeated challenges did not establish consistent individual symptom patterns; the two final participants each reacted to only one of three MSG-with-food challenges.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1a39319d-3cd7-5af5-adb0-d11f846479d5","mechanism_event_label":"An initial response and a reproducible sensitivity are different findings.","subject":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"object":{"id":"0868ad97-9dad-5927-b402-95a6ba025ba7","slug":"human-msg-challenge-symptoms","display_name":"Human symptoms during blinded MSG challenge","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1a39319d-3cd7-5af5-adb0-d11f846479d5","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-retest-inconsistency-event","event_type":"observed_relationship","label":"An initial response and a reproducible sensitivity are different findings.","description":"Repeated challenges did not establish consistent individual symptom patterns; the two final participants each reacted to only one of three MSG-with-food challenges.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0868ad97-9dad-5927-b402-95a6ba025ba7","slug":"human-msg-challenge-symptoms","display_name":"Human symptoms during blinded MSG challenge","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Sequential retesting in the same study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Only two people reached the food protocol, so it is not a large general test of all meals.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An initial response and a reproducible sensitivity are different findings.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Multicenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate. · 2000 · https://pubmed.ncbi.nlm.nih.gov/11080723/ · DOI 10.1067/mai.2000.110794","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"37626526-12f5-5fbd-a3ae-7f11bdc532a8","evidence_kind":"source_excerpt","locator":"Lines 266-272","start_line":266,"end_line":272,"excerpt":"## monosodium-glutamate-retest-inconsistency\nAn initial response and a reproducible sensitivity are different findings.\nRepeated challenges did not establish consistent individual symptom patterns; the two final participants each reacted to only one of three MSG-with-food challenges.\nModel: Sequential retesting in the same study.\nLimitations: Only two people reached the food protocol, so it is not a large general test of all meals.\nEvidence access: Primary abstract\nMulticenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate. · 2000 · https://pubmed.ncbi.nlm.nih.gov/11080723/ · DOI 10.1067/mai.2000.110794","model_system":"Sequential retesting in the same study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"90a81fe5-8622-52f6-b4db-04899206c2b0","stable_key":"import-561b2b40-5b59-548f-a749-f357f7e2304c","title":"Monosodium Glutamate (MSG): taste, gut sensing, exposure and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"53052c19ee82d400eff7d82ffa3cff74747c7f91a8d173efa3f46eba6bd87cce","revision_id":"fdb64139-32f4-537e-bb0f-f242f2779da8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}