{"id":"827e337d-212c-5641-b7d3-7d7f023e5e58","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-carvedilol-rat","predicate":"increases_oral_exposure","statement":"Coadministered myricetin increased oral carvedilol AUC by 52.0–85.1% in the reported rat comparisons.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6b00fe7d-d6d7-50ba-8601-7f52dae0ace4","mechanism_event_label":"A whole-animal drug exposure change was observed.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"3fefed17-b08d-57e0-af5d-deb43896e203","slug":"carvedilol","display_name":"Carvedilol","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"6b00fe7d-d6d7-50ba-8601-7f52dae0ace4","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-carvedilol-rat-event","event_type":"observed_relationship","label":"A whole-animal drug exposure change was observed.","description":"Coadministered myricetin increased oral carvedilol AUC by 52.0–85.1% in the reported rat comparisons.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3fefed17-b08d-57e0-af5d-deb43896e203","slug":"carvedilol","display_name":"Carvedilol","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat oral versus intravenous carvedilol pharmacokinetics.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"CYP and P-gp contributions were proposed, not separately proven; no human dose adjustment follows.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A whole-animal drug exposure change was observed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of myricetin on the bioavailability of carvedilol in rats. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22132944/ · DOI 10.3109/13880209.2011.611141","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4b66d0d6-417a-5c63-bdd6-0e0a2efe0b09","evidence_kind":"source_excerpt","locator":"Lines 244-250","start_line":244,"end_line":250,"excerpt":"## myricetin-carvedilol-rat\nA whole-animal drug exposure change was observed.\nCoadministered myricetin increased oral carvedilol AUC by 52.0–85.1% in the reported rat comparisons.\nModel: Rat oral versus intravenous carvedilol pharmacokinetics.\nLimitations: CYP and P-gp contributions were proposed, not separately proven; no human dose adjustment follows.\nEvidence access: Primary abstract\nEffects of myricetin on the bioavailability of carvedilol in rats. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22132944/ · DOI 10.3109/13880209.2011.611141","model_system":"Rat oral versus intravenous carvedilol pharmacokinetics.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0abf512275cf3aae9e4ec8544f1cde97e0155d0cfb5be12a193cdd5a898386a7","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}