{"id":"81f1bc5a-57ce-5d7f-98c2-ca2b80caa34c","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-urine-variability","predicate":"shows-within-person-variability","statement":"Mean within-person variability was 32% for measured 24-hour iodine excretion, 33% for estimated 24-hour excretion and 38% for spot urinary iodine concentration.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5f977ba3-8c6d-538a-88cd-460f20b2c521","mechanism_event_label":"One urine result can vary substantially within the same person.","subject":{"id":"240520a5-5777-5f4f-aa45-1dfca6abc55d","slug":"urinary-iodine-concentration","display_name":"Urinary iodine concentration","entity_type_key":"cellular_process"},"object":{"id":"2c5bea4e-870e-5816-a988-7e4010c7049d","slug":"urinary-iodine-excretion","display_name":"Twenty-four-hour urinary iodine excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5f977ba3-8c6d-538a-88cd-460f20b2c521","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-urine-variability-event","event_type":"observed_intervention","label":"One urine result can vary substantially within the same person.","description":"Mean within-person variability was 32% for measured 24-hour iodine excretion, 33% for estimated 24-hour excretion and 38% for spot urinary iodine concentration.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"nutrient being estimated","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"240520a5-5777-5f4f-aa45-1dfca6abc55d","slug":"urinary-iodine-concentration","display_name":"Urinary iodine concentration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2c5bea4e-870e-5816-a988-7e4010c7049d","slug":"urinary-iodine-excretion","display_name":"Twenty-four-hour urinary iodine excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Prospective 15-month repeated-collection study in 22 healthy Swiss women aged 52–77","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"341 24-hour urine collections and 177 corresponding fasting second-void morning spot samples; within-person variability used for precision estimates.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The sample-number estimate is specific to this population, sampling method and 20% precision target. It is not a universal instruction to collect ten specimens or a validated single-person diagnostic cutoff.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"One urine result can vary substantially within the same person.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iod-clin-konig2011] Ten repeat collections for urinary iodine from spot samples or 24-hour samples are needed to reliably estimate individual iodine status in women. (2011). https://pubmed.ncbi.nlm.nih.gov/21918061/ DOI: 10.3945/jn.111.144071","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Spot and24-hour urine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"088f4be8-f1c7-5300-bbce-9cc429fc20e7","evidence_kind":"source_excerpt","locator":"Lines 1426-1438","start_line":1426,"end_line":1438,"excerpt":"### iod-clin-urine-variability\nMean within-person variability was 32% for measured 24-hour iodine excretion, 33% for estimated 24-hour excretion and 38% for spot urinary iodine concentration.\nCondition category: biomarker_context\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: One urine result can vary substantially within the same person.\norganism: Homo sapiens\ntissue_or_cell_type: Spot and24-hour urine\nexperimental_model: Prospective 15-month repeated-collection study in 22 healthy Swiss women aged 52–77\nlimitations: The sample-number estimate is specific to this population, sampling method and 20% precision target. It is not a universal instruction to collect ten specimens or a validated single-person diagnostic cutoff.\nexposure: 341 24-hour urine collections and 177 corresponding fasting second-void morning spot samples; within-person variability used for precision estimates.\ncross_nutrient: false\nevidence_location: Primary indexed abstract.\n[iod-clin-konig2011] Ten repeat collections for urinary iodine from spot samples or 24-hour samples are needed to reliably estimate individual iodine status in women. (2011). https://pubmed.ncbi.nlm.nih.gov/21918061/ DOI: 10.3945/jn.111.144071","model_system":"Prospective 15-month repeated-collection study in 22 healthy Swiss women aged 52–77","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iod-clin-konig2011] Ten repeat collections for urinary iodine from spot samples or 24-hour samples are needed to reliably estimate individual iodine status in women. (2011). https://pubmed.ncbi.nlm.nih.gov/21918061/ DOI: 10.3945/jn.111.144071","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"76da623d-a34a-5a5c-a942-d7571a85c486","stable_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a4885eb6f58bad4a4514c958b63834619e57b10aa7f694aa97d0f65c7d36548f","revision_id":"ea8001a1-b576-5eda-a193-883c7ad59b73","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}