{"id":"81d69f17-9fcf-5050-bcae-67d880ab0001","stable_key":"db0fc92e-b5ef-5667-a4c5-3ef257edbc9b:glutathione-oral-2015-nk","predicate":"increases_in_subset","statement":"At three months, high-dose NK cytotoxicity exceeded placebo by more than twofold in the immune subset.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0840f502-15a1-5914-9c3c-9768d0644e52","mechanism_event_label":"An immune assay changed; clinical infection protection was not established.","subject":{"id":"438e5cf7-7efb-589c-8f2d-3ea840bf72a2","slug":"oral-reduced-gsh-2015","display_name":"Oral reduced glutathione regimens in the 2015 trial","entity_type_key":"chemical_species"},"object":{"id":"b7ff5c49-3f93-5d17-a402-dd4089d68166","slug":"nk-cytotoxicity-2015","display_name":"Natural-killer-cell cytotoxicity in the 2015 GSH trial subset","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0840f502-15a1-5914-9c3c-9768d0644e52","stable_key":"db0fc92e-b5ef-5667-a4c5-3ef257edbc9b:glutathione-oral-2015-nk-event","event_type":"observed_intervention","label":"An immune assay changed; clinical infection protection was not established.","description":"At three months, high-dose NK cytotoxicity exceeded placebo by more than twofold in the immune subset.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"supplemented_molecule","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"438e5cf7-7efb-589c-8f2d-3ea840bf72a2","slug":"oral-reduced-gsh-2015","display_name":"Oral reduced glutathione regimens in the 2015 trial","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b7ff5c49-3f93-5d17-a402-dd4089d68166","slug":"nk-cytotoxicity-2015","display_name":"Natural-killer-cell cytotoxicity in the 2015 GSH trial subset","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/glutathione-research/24791752.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b65406018e3d344f25ad877adb47c73cce7431e9ba5e8d280a35aae066112388\", \"start_char\": 0, \"end_char\": 1596, \"text_sha256\": \"b65406018e3d344f25ad877adb47c73cce7431e9ba5e8d280a35aae066112388\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six-month randomized double-blind placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"250 or 1000 mg/day oral GSH; one-month washout","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Pool increases reported relative to baseline; NK comparison was versus placebo. Biomarkers do not prove fewer illnesses or longer life.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glutathione research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"An immune assay changed; clinical infection protection was not established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[glutathione-p24791752] Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. (2015). https://pubmed.ncbi.nlm.nih.gov/24791752/ DOI: 10.1007/s00394-014-0706-z","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"54 nonsmoking adults; immune subset","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"31f8750a-460a-5fa4-bb1c-c1ebcb9da813","evidence_kind":"source_excerpt","locator":"Lines 1243-1254","start_line":1243,"end_line":1254,"excerpt":"### glutathione-oral-2015-nk\nAt three months, high-dose NK cytotoxicity exceeded placebo by more than twofold in the immune subset.\nCondition category: normal\nnutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An immune assay changed; clinical infection protection was not established.\norganism: Human\ntissue_or_cell_type: 54 nonsmoking adults; immune subset\nexperimental_model: Six-month randomized double-blind placebo-controlled trial\nlimitations: Pool increases reported relative to baseline; NK comparison was versus placebo. Biomarkers do not prove fewer illnesses or longer life.\nexposure: 250 or 1000 mg/day oral GSH; one-month washout\nevidence_span: {\"source_cache\": \"artifacts/glutathione-research/24791752.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b65406018e3d344f25ad877adb47c73cce7431e9ba5e8d280a35aae066112388\", \"start_char\": 0, \"end_char\": 1596, \"text_sha256\": \"b65406018e3d344f25ad877adb47c73cce7431e9ba5e8d280a35aae066112388\"}\n[glutathione-p24791752] Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. (2015). https://pubmed.ncbi.nlm.nih.gov/24791752/ DOI: 10.1007/s00394-014-0706-z","model_system":"Six-month randomized double-blind placebo-controlled trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [glutathione-p24791752] Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. (2015). https://pubmed.ncbi.nlm.nih.gov/24791752/ DOI: 10.1007/s00394-014-0706-z","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9b7417fd-059d-5683-b452-71d1e3cf82d0","stable_key":"import-db0fc92e-b5ef-5667-a4c5-3ef257edbc9b","title":"Glutathione: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"2a5740c4a7e770aafe883fea47909b18bf5e174f211749935130a50f9dea2753","revision_id":"a64016dd-4b72-5954-a72d-0e61de854073","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}