{"id":"81b6f0c0-4b99-5dda-a4ff-03f2a9d6c65b","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-pantethine-nonhdl-2014","predicate":"reduces","statement":"Non-HDL cholesterol differences in the 32-person trial were trends at weeks 8 and 12 and reached significance at week 16 (P=0.042).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"8e73b5c1-1e05-512d-8c47-2d57a5589f35","mechanism_event_label":"The broader non-HDL marker reached statistical significance only at the later measurement.","subject":{"id":"c0600873-c581-5429-91cb-414f179823ce","slug":"pantethine","display_name":"Pantethine","entity_type_key":"small_molecule"},"object":{"id":"5f6cc79b-2f53-51de-abe8-0d95693ba03b","slug":"non-hdl-cholesterol-concentration","display_name":"Non-HDL cholesterol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8e73b5c1-1e05-512d-8c47-2d57a5589f35","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-pantethine-nonhdl-2014-event","event_type":"observed_intervention","label":"The broader non-HDL marker reached statistical significance only at the later measurement.","description":"Non-HDL cholesterol differences in the 32-person trial were trends at weeks 8 and 12 and reached significance at week 16 (P=0.042).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c0600873-c581-5429-91cb-414f179823ce","slug":"pantethine","display_name":"Pantethine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5f6cc79b-2f53-51de-abe8-0d95693ba03b","slug":"non-hdl-cholesterol-concentration","display_name":"Non-HDL cholesterol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract; full article retrieval was unavailable.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized triple-blind placebo- and diet-controlled trial in 32 adults eligible for statin therapy under the study criteria","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Pantethine 600 mg/day for weeks 1–8 and 900 mg/day for weeks 9–16.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small short trial with industry-associated authors and surrogate outcomes; not evidence that pantothenic acid has the same effects or that events or mortality improve.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The broader non-HDL marker reached statistical significance only at the later measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-clin-evans2014] Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. (2014). https://pubmed.ncbi.nlm.nih.gov/24600231/ DOI: 10.2147/vhrm.s57116","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Circulating lipids","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bdd8282c-5beb-562c-98cc-ba61b9a20bd5","evidence_kind":"source_excerpt","locator":"Lines 1425-1437","start_line":1425,"end_line":1437,"excerpt":"### b5-clin-pantethine-nonhdl-2014\nNon-HDL cholesterol differences in the 32-person trial were trends at weeks 8 and 12 and reached significance at week 16 (P=0.042).\nCondition category: normal\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The broader non-HDL marker reached statistical significance only at the later measurement.\norganism: Homo sapiens\ntissue_or_cell_type: Circulating lipids\nexperimental_model: Randomized triple-blind placebo- and diet-controlled trial in 32 adults eligible for statin therapy under the study criteria\nlimitations: Small short trial with industry-associated authors and surrogate outcomes; not evidence that pantothenic acid has the same effects or that events or mortality improve.\nexposure: Pantethine 600 mg/day for weeks 1–8 and 900 mg/day for weeks 9–16.\ncross_nutrient: false\nevidence_location: Primary indexed abstract; full article retrieval was unavailable.\n[b5-clin-evans2014] Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. 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