{"id":"818f9615-74de-5f09-9848-2750b09ce0eb","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-inositol-rescue","predicate":"attenuates","statement":"Added myo-inositol attenuated lithium-enhanced mutant-protein clearance in PC12 cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6604ce16-871d-5335-bd69-0acb0711bc21","mechanism_event_label":"A connected nutrient can counter an experimentally induced response.","subject":{"id":"50afe95c-f542-5511-ba8b-c2ff2b037977","slug":"myo-inositol","display_name":"Myo-inositol","entity_type_key":"small_molecule"},"object":{"id":"c0048233-200a-50e4-acfa-7c93e4547234","slug":"rat-pc12-mutant-protein-clearance","display_name":"Rat PC12-cell clearance of expressed mutant proteins","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6604ce16-871d-5335-bd69-0acb0711bc21","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-inositol-rescue-event","event_type":"observed_relationship","label":"A connected nutrient can counter an experimentally induced response.","description":"Added myo-inositol attenuated lithium-enhanced mutant-protein clearance in PC12 cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"50afe95c-f542-5511-ba8b-c2ff2b037977","slug":"myo-inositol","display_name":"Myo-inositol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c0048233-200a-50e4-acfa-7c93e4547234","slug":"rat-pc12-mutant-protein-clearance","display_name":"Rat PC12-cell clearance of expressed mutant proteins","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat PC12; 1 mM myo-inositol with 10 mM LiCl.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Time-dependent and incomplete effects; not proof that oral inositol reverses mood stabilization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"A connected nutrient can counter an experimentally induced response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Lithium induces autophagy by inhibiting inositol monophosphatase. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16186256/ · DOI 10.1083/jcb.200504035","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"43775502-2144-5d2f-bab5-57e4082351f3","evidence_kind":"source_excerpt","locator":"Lines 104-110","start_line":104,"end_line":110,"excerpt":"## lithium-inositol-rescue\nA connected nutrient can counter an experimentally induced response.\nAdded myo-inositol attenuated lithium-enhanced mutant-protein clearance in PC12 cells.\nModel: Rat PC12; 1 mM myo-inositol with 10 mM LiCl.\nLimitations: Time-dependent and incomplete effects; not proof that oral inositol reverses mood stabilization.\nEvidence access: Primary full text\nLithium induces autophagy by inhibiting inositol monophosphatase. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16186256/ · DOI 10.1083/jcb.200504035","model_system":"Rat PC12; 1 mM myo-inositol with 10 mM LiCl.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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