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Enzyme activity is not a clinical benefit or dietary response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Molybdenum research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens protein","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"One variant raised several outputs at once.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mo-p37713777] Natural mutations of human XDH promote the nitrite (NO2-)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health? (2023). https://pubmed.ncbi.nlm.nih.gov/37713777/ DOI: 10.1016/j.redox.2023.102864","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Purified human enzyme","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a339e132-d10d-5cc4-9bac-cff2a05824ac","evidence_kind":"source_excerpt","locator":"Lines 807-818","start_line":807,"end_line":818,"excerpt":"### mo-xor-h1221r\nHis1221Arg increased urate, superoxide and NO formation relative to wild type in xanthine-supplied assays.\nCondition category: normal\nnutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: One variant raised several outputs at once.\norganism: Homo sapiens protein\ntissue_or_cell_type: Purified human enzyme\nexperimental_model: Recombinant human XDH variants with urate, superoxide and NO assays\nlimitations: The 2023 Fig. 6E corrigendum corrects a displayed panel; authors state data and conclusions are unchanged. Enzyme activity is not a clinical benefit or dietary response.\nexposure: Xanthine, oxygen and inorganic nitrite assays\nevidence_span: {\"source_cache\": \"artifacts/molybdenum-research/37713777.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"30e93ea24784120403bef1dfe72cf46411f1af88946b9cc1cba3d4c45a367bf9\", \"start_char\": 0, \"end_char\": 1655, \"text_sha256\": \"30e93ea24784120403bef1dfe72cf46411f1af88946b9cc1cba3d4c45a367bf9\"}\n[mo-p37713777] Natural mutations of human XDH promote the nitrite (NO2-)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health? (2023). https://pubmed.ncbi.nlm.nih.gov/37713777/ DOI: 10.1016/j.redox.2023.102864","model_system":"Recombinant human XDH variants with urate, superoxide and NO assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mo-p37713777] Natural mutations of human XDH promote the nitrite (NO2-)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health? 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