{"id":"815ba017-3f45-571f-a36d-0d0e95fa595f","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-hormone-withdrawal","predicate":"reduces","statement":"Somatostatin suppressed splanchnic glucose output by 50–100% for five hours after a 60-hour fast; the overnight-fast reduction was transient.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d2e4bdc5-f7d1-5bb5-8338-75eb8b11cf18","mechanism_event_label":"Hormonal control changed with the fasting state.","subject":{"id":"2b03b562-ceb7-5510-98c5-8ba15d577cf7","slug":"combined-insulin-glucagon-suppression","display_name":"Somatostatin-induced combined insulin and glucagon suppression","entity_type_key":"cellular_process"},"object":{"id":"e78adb0b-22fe-52da-bb7f-6c1603fd4859","slug":"splanchnic-glucose-output","display_name":"Splanchnic glucose output","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d2e4bdc5-f7d1-5bb5-8338-75eb8b11cf18","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-hormone-withdrawal-event","event_type":"observed_relationship","label":"Hormonal control changed with the fasting state.","description":"Somatostatin suppressed splanchnic glucose output by 50–100% for five hours after a 60-hour fast; the overnight-fast reduction was transient.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2b03b562-ceb7-5510-98c5-8ba15d577cf7","slug":"combined-insulin-glucagon-suppression","display_name":"Somatostatin-induced combined insulin and glucagon suppression","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e78adb0b-22fe-52da-bb7f-6c1603fd4859","slug":"splanchnic-glucose-output","display_name":"Splanchnic glucose output","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"937e9e5b-070e-5a7e-9f9f-fbbd1fbac5d0","slug":"glucagon","display_name":"Glucagon","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy humans; somatostatin, glucose infusion to maintain euglycemia, organ exchange measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Insulin and glucagon were both suppressed. The experiment does not isolate glucagon alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"Hormonal control changed with the fasting state.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Role of basal glucagon levels in the regulation of splanchnic glucose output and ketogenesis in insulin-deficient humans. · 1984 · https://pubmed.ncbi.nlm.nih.gov/6146427/ · DOI 10.1111/j.1475-097x.1984.tb00117.x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"755cb56f-db06-5aba-9e47-08cf3992aa5d","evidence_kind":"source_excerpt","locator":"Lines 96-102","start_line":96,"end_line":102,"excerpt":"## fast-hormone-withdrawal\nHormonal control changed with the fasting state.\nSomatostatin suppressed splanchnic glucose output by 50–100% for five hours after a 60-hour fast; the overnight-fast reduction was transient.\nModel: Healthy humans; somatostatin, glucose infusion to maintain euglycemia, organ exchange measurements.\nLimitations: Insulin and glucagon were both suppressed. The experiment does not isolate glucagon alone.\nEvidence access: Primary abstract\nRole of basal glucagon levels in the regulation of splanchnic glucose output and ketogenesis in insulin-deficient humans. · 1984 · https://pubmed.ncbi.nlm.nih.gov/6146427/ · DOI 10.1111/j.1475-097x.1984.tb00117.x","model_system":"Healthy humans; somatostatin, glucose infusion to maintain euglycemia, organ exchange measurements.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}