{"id":"81540454-b429-5fe6-a178-6588a174b065","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-human-sulfate","predicate":"oral_administration_yields","statement":"After oral luteolin aglycone in human volunteers, luteolin 3′-O-sulfate was the principal plasma form identified.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a3ab2739-2dee-562a-a4b1-14ea2080f61c","mechanism_event_label":"The swallowed molecule and the main measured blood form differ.","subject":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"object":{"id":"64d39ecb-18b8-5f67-8514-501180eccc69","slug":"luteolin-3-prime-o-sulfate","display_name":"Luteolin 3′-O-sulfate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"a3ab2739-2dee-562a-a4b1-14ea2080f61c","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-human-sulfate-event","event_type":"observed_relationship","label":"The swallowed molecule and the main measured blood form differ.","description":"After oral luteolin aglycone in human volunteers, luteolin 3′-O-sulfate was the principal plasma form identified.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"64d39ecb-18b8-5f67-8514-501180eccc69","slug":"luteolin-3-prime-o-sulfate","display_name":"Luteolin 3′-O-sulfate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human oral exposure; primary abstract does not specify dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not establish free intracellular luteolin or clinical target engagement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The swallowed molecule and the main measured blood form differ.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Absorption and Metabolism of Luteolin in Rats and Humans in Relation to in Vitro Anti-inflammatory Effects. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30280574/ · DOI 10.1021/acs.jafc.8b03273","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"346208f9-333f-59ab-8576-e68a97e195b3","evidence_kind":"source_excerpt","locator":"Lines 12-18","start_line":12,"end_line":18,"excerpt":"## luteolin-human-sulfate\nThe swallowed molecule and the main measured blood form differ.\nAfter oral luteolin aglycone in human volunteers, luteolin 3′-O-sulfate was the principal plasma form identified.\nModel: Human oral exposure; primary abstract does not specify dose.\nLimitations: Does not establish free intracellular luteolin or clinical target engagement.\nEvidence access: Primary abstract\nAbsorption and Metabolism of Luteolin in Rats and Humans in Relation to in Vitro Anti-inflammatory Effects. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30280574/ · DOI 10.1021/acs.jafc.8b03273","model_system":"Human oral exposure; primary abstract does not specify dose.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"fd6ea0b1cef8d1c9965270494bfa815de14f679044f0b5d5d7bbf4904630ad76","revision_id":"c9a3dd80-c7e6-5fb4-bc91-8db265e7c8de","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}