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Cell-line concentrations are not stated in the abstract and are not assumed here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin.","comparator":null,"unit":null,"notes":"","entity":{"slug":"dihydrocapsaicin","display_name":"Dihydrocapsaicin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human cells and mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"It kills glioma cells through the mitochondria while largely sparing normal cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[dhc-p27748914] Capsaicin and dihydrocapsaicin induce apoptosis in human glioma cells via ROS and Ca2+‑mediated mitochondrial pathway. 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Cell-line concentrations are not stated in the abstract and are not assumed here.\nexposure: Capsaicin and dihydrocapsaicin applied across doses and times, with L929 normal fibroblasts as a selectivity control\nevidence_span: {\"source_cache\": \"artifacts/dihydrocapsaicin-research/27748914.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ffc172fb64714099772462ba33304b69637efac75f1f218f2032e26bbc32dc90\", \"start_char\": 0, \"end_char\": 1610, \"text_sha256\": \"ffc172fb64714099772462ba33304b69637efac75f1f218f2032e26bbc32dc90\"}\n[dhc-p27748914] Capsaicin and dihydrocapsaicin induce apoptosis in human glioma cells via ROS and Ca2+‑mediated mitochondrial pathway. 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