{"id":"8109032e-4aa3-5f31-b343-c0924a9b5be5","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-deficiency-blunts-renal-pth-camp-response","predicate":"elicits-blunted-response-in","statement":"Parathyroid extract produced only a small urinary cAMP response in the two Mg-deficient patients tested, while glucagon-stimulated plasma cAMP responses were preserved.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"7620ec88-1074-5cef-b3da-a1ae4ed2cf3a","mechanism_event_label":"The kidney responded weakly to the PTH challenge, but another hormone/cAMP response remained functional; Mg deficiency did not disable all signaling equally.","subject":{"id":"e162b0ab-1449-5471-b3c3-4638a0fa3a96","slug":"pth","display_name":"Parathyroid hormone / PTH","entity_type_key":"protein"},"object":{"id":"46f1b617-0a8d-5dfe-b6fa-d5fd23745898","slug":"urinary-camp-excretion","display_name":"Urinary cyclic AMP excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7620ec88-1074-5cef-b3da-a1ae4ed2cf3a","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-deficiency-blunts-renal-pth-camp-response-event","event_type":"biochemical_relationship","label":"The kidney responded weakly to the PTH challenge, but another hormone/cAMP response remained functional; Mg deficiency did not disable all signaling equally.","description":"Parathyroid extract produced only a small urinary cAMP response in the two Mg-deficient patients tested, while glucagon-stimulated plasma cAMP responses were preserved.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9cc3323e-3a7f-5be5-91ae-78dab284fb81","slug":"cyclic-amp","display_name":"Cyclic adenosine monophosphate","entity_type_key":"small_molecule"},"role":"measured messenger","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6ffdecce-6117-5eee-a1b2-f03a6fb6c272","slug":"pth1r","display_name":"Parathyroid hormone receptor 1 / PTH1R","entity_type_key":"protein"},"role":"upstream receptor context, not directly assayed","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e162b0ab-1449-5471-b3c3-4638a0fa3a96","slug":"pth","display_name":"Parathyroid hormone / PTH","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"46f1b617-0a8d-5dfe-b6fa-d5fd23745898","slug":"urinary-camp-excretion","display_name":"Urinary cyclic AMP excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"magnesium -> PTH -> calcium","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human hypomagnesemic hypocalcemia clinical study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Only two challenge studies; urinary cAMP is an organ-response marker, not direct measurement of PTH1R binding or adenylyl-cyclase Mg occupancy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The kidney responded weakly to the PTH challenge, but another hormone/cAMP response remained functional; Mg deficiency did not disable all signaling equally.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[rude-1976-human-pth-resistance] Functional hypoparathyroidism and parathyroid hormone end-organ resistance in human magnesium deficiency (1976). https://pubmed.ncbi.nlm.nih.gov/182417/ DOI: 10.1111/j.1365-2265.1976.tb01947.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood; parathyroid-kidney axis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"cc79843a-13f5-57ad-bf78-36aece80255b","evidence_kind":"source_excerpt","locator":"Lines 337-347","start_line":337,"end_line":347,"excerpt":"### mg-deficiency-blunts-renal-pth-camp-response\nParathyroid extract produced only a small urinary cAMP response in the two Mg-deficient patients tested, while glucagon-stimulated plasma cAMP responses were preserved.\nCondition category: nutrient_deficiency\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The kidney responded weakly to the PTH challenge, but another hormone/cAMP response remained functional; Mg deficiency did not disable all signaling equally.\norganism: Homo sapiens\ntissue_or_cell_type: Blood; parathyroid-kidney axis\nexperimental_model: Human hypomagnesemic hypocalcemia clinical study\nlimitations: Only two challenge studies; urinary cAMP is an organ-response marker, not direct measurement of PTH1R binding or adenylyl-cyclase Mg occupancy.\ncross_nutrient: magnesium -> PTH -> calcium\n[rude-1976-human-pth-resistance] Functional hypoparathyroidism and parathyroid hormone end-organ resistance in human magnesium deficiency (1976). https://pubmed.ncbi.nlm.nih.gov/182417/ DOI: 10.1111/j.1365-2265.1976.tb01947.x","model_system":"Human hypomagnesemic hypocalcemia clinical study","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [rude-1976-human-pth-resistance] Functional hypoparathyroidism and parathyroid hormone end-organ resistance in human magnesium deficiency (1976). https://pubmed.ncbi.nlm.nih.gov/182417/ DOI: 10.1111/j.1365-2265.1976.tb01947.x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}