{"id":"80fd388e-8b0e-516c-b5d4-476153fb4dd2","stable_key":"788beb7b-7928-5f89-83d4-5556abf3702c:fulvic-acid-airway-iron-import","predicate":"increases","statement":"Reference fulvic fractions increased iron import in respiratory epithelial cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ce95bfaf-20d6-503a-b159-7f8ac8c31cba","mechanism_event_label":"Cells changed their iron handling after direct exposure.","subject":{"id":"b7371865-cb83-5b2e-a5ad-45edfeea09c5","slug":"suwannee-river-fulvic-acid","display_name":"Suwannee River fulvic acid reference material","entity_type_key":"chemical_species"},"object":{"id":"4f1eba14-27a2-58ff-a7e4-02a2df71ab0e","slug":"human-airway-iron-import-fa","display_name":"Iron import in fulvic-exposed respiratory epithelial cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ce95bfaf-20d6-503a-b159-7f8ac8c31cba","stable_key":"788beb7b-7928-5f89-83d4-5556abf3702c:fulvic-acid-airway-iron-import-event","event_type":"observed_relationship","label":"Cells changed their iron handling after direct exposure.","description":"Reference fulvic fractions increased iron import in respiratory epithelial cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b7371865-cb83-5b2e-a5ad-45edfeea09c5","slug":"suwannee-river-fulvic-acid","display_name":"Suwannee River fulvic acid reference material","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4f1eba14-27a2-58ff-a7e4-02a2df71ab0e","slug":"human-airway-iron-import-fa","display_name":"Iron import in fulvic-exposed respiratory epithelial cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0aa6c0fc-8374-56e0-b172-6c40b6366d21","slug":"fulvic-acid","display_name":"Fulvic acid (heterogeneous humic fraction)","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bf6dbaf0-1379-5ae1-9d27-aa46fab2e49a","slug":"nordic-fulvic-acid","display_name":"Nordic fulvic acid reference material","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human respiratory epithelial-cell exposure to Suwannee River/Nordic reference fulvic fractions; comparison with smoke water-soluble fractions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Abstract access; exposure concentration and duration require full-method verification. Increased iron import is consistent with compensatory iron stress, not direct quantification of every intracellular available-iron pool. These are airway-cell exposures, not an oral trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fulvic acid collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fulvic-acid","display_name":"Fulvic acid (heterogeneous humic fraction)","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Cells changed their iron handling after direct exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A Fulvic Acid-like Substance Participates in the Pro-inflammatory Effects of Cigarette Smoke and Wood Smoke Particles. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32191033/ · DOI 10.1021/acs.chemrestox.0c00036","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6cde554f-8c99-5640-b9ad-0a91f32a9e6a","evidence_kind":"source_excerpt","locator":"Lines 212-218","start_line":212,"end_line":218,"excerpt":"## fulvic-acid-airway-iron-import\nCells changed their iron handling after direct exposure.\nReference fulvic fractions increased iron import in respiratory epithelial cells.\nModel: Human respiratory epithelial-cell exposure to Suwannee River/Nordic reference fulvic fractions; comparison with smoke water-soluble fractions.\nLimitations: Abstract access; exposure concentration and duration require full-method verification. Increased iron import is consistent with compensatory iron stress, not direct quantification of every intracellular available-iron pool. These are airway-cell exposures, not an oral trial.\nEvidence access: Primary abstract\nA Fulvic Acid-like Substance Participates in the Pro-inflammatory Effects of Cigarette Smoke and Wood Smoke Particles. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32191033/ · DOI 10.1021/acs.chemrestox.0c00036","model_system":"Human respiratory epithelial-cell exposure to Suwannee River/Nordic reference fulvic fractions; comparison with smoke water-soluble fractions.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b00a1818-46e4-52cc-8dfe-a647d5c08ed7","stable_key":"import-788beb7b-7928-5f89-83d4-5556abf3702c","title":"Fulvic acid: mixture identity, mineral chemistry, signaling and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"52c2c3ee6bb23d943a40e1c39dd9de5cca7acd6efa72479cb824149e85cc7968","revision_id":"94dfc01b-c93e-55ff-8f48-bb2e9a1979f6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}