{"id":"80bfc8af-d5d0-5d3b-bb1d-294eb85de55b","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-gambia-hemoglobin","predicate":"increased_hemoglobin_in_deficient_men","statement":"Riboflavin supplementation improved B2 status and hemoglobin in deficient Gambian men; low plasma ferritin did not change.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"ccde2f09-fa72-5450-b641-b351ee42775a","mechanism_event_label":"Hemoglobin improved even though the measured storage marker stayed low.","subject":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"object":{"id":"2f3a8d0b-7b92-58d2-afc9-dd26a7cd1e0e","slug":"blood-hemoglobin-concentration","display_name":"Blood hemoglobin concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ccde2f09-fa72-5450-b641-b351ee42775a","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-gambia-hemoglobin-event","event_type":"observed_intervention","label":"Hemoglobin improved even though the measured storage marker stayed low.","description":"Riboflavin supplementation improved B2 status and hemoglobin in deficient Gambian men; low plasma ferritin did not change.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"nutrient_partner","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2f3a8d0b-7b92-58d2-afc9-dd26a7cd1e0e","slug":"blood-hemoglobin-concentration","display_name":"Blood hemoglobin concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"B2 and iron supply can constrain different parts of erythropoiesis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled supplementation study in riboflavin-deficient Gambian men with hemoglobin below 11.5 g/dL; stable-isotope iron absorption.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Oral riboflavin versus no riboflavin; 3.38 mg 58Fe test dose before and after intervention; treatment dose not inferred from accessed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Controlled study in anemic deficient men; the specific marrow or mobilization mechanism was inferred, not directly established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Riboflavin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Hemoglobin improved even though the measured storage marker stayed low.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b2-fairweather1992] Riboflavin deficiency and iron absorption in adult Gambian men (1992). https://pubmed.ncbi.nlm.nih.gov/1590670/ DOI: 10.1159/000177696","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human clinical setting","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"874cc273-e2ad-5328-952e-7fe59bb0ad56","evidence_kind":"source_excerpt","locator":"Lines 1578-1589","start_line":1578,"end_line":1589,"excerpt":"### b2-gambia-hemoglobin\nRiboflavin supplementation improved B2 status and hemoglobin in deficient Gambian men; low plasma ferritin did not change.\nCondition category: nutrient_deficiency\nnutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Hemoglobin improved even though the measured storage marker stayed low.\norganism: Homo sapiens\ntissue_or_cell_type: Human clinical setting\nexperimental_model: Controlled supplementation study in riboflavin-deficient Gambian men with hemoglobin below 11.5 g/dL; stable-isotope iron absorption.\nlimitations: Controlled study in anemic deficient men; the specific marrow or mobilization mechanism was inferred, not directly established.\nexposure: Oral riboflavin versus no riboflavin; 3.38 mg 58Fe test dose before and after intervention; treatment dose not inferred from accessed abstract.\ncross_nutrient: B2 and iron supply can constrain different parts of erythropoiesis.\n[b2-fairweather1992] Riboflavin deficiency and iron absorption in adult Gambian men (1992). https://pubmed.ncbi.nlm.nih.gov/1590670/ DOI: 10.1159/000177696","model_system":"Controlled supplementation study in riboflavin-deficient Gambian men with hemoglobin below 11.5 g/dL; stable-isotope iron absorption.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b2-fairweather1992] Riboflavin deficiency and iron absorption in adult Gambian men (1992). https://pubmed.ncbi.nlm.nih.gov/1590670/ DOI: 10.1159/000177696","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f7c9578-82bf-5e2d-b5c4-72a79fb4f6af","stable_key":"import-548ab9d6-3a9b-5bed-879c-17d03813b636","title":"Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"680cb6bc8249877f2410f551807f10d390fdd719014137d7414ba3420e29228d","revision_id":"7a61e299-908d-5372-860b-99ed190f9d7a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}