{"id":"80afedc8-cbc3-52e8-b1e9-f2e690ae8198","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-pdt-killing","predicate":"potentiates_killing","statement":"KI increased light/Rose-bengal killing by up to six logs in the tested bacterial and Candida systems.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d5361eef-4726-5504-b0df-00be42a03f0c","mechanism_event_label":"KI amplified an externally activated antimicrobial reaction.","subject":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"object":{"id":"30b8a5c8-dbdd-5a4a-87c7-86223b5e62b4","slug":"microbial-viability","display_name":"Microbial viability in the specified assay","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d5361eef-4726-5504-b0df-00be42a03f0c","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-pdt-killing-event","event_type":"observed_relationship","label":"KI amplified an externally activated antimicrobial reaction.","description":"KI increased light/Rose-bengal killing by up to six logs in the tested bacterial and Candida systems.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"30b8a5c8-dbdd-5a4a-87c7-86223b5e62b4","slug":"microbial-viability","display_name":"Microbial viability in the specified assay","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"dcc30c48-e49e-5684-b289-082ce74d06bd","slug":"rose-bengal","display_name":"Rose bengal","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ac4a9e3e-1454-5802-82a3-3b3b18afc417","slug":"singlet-oxygen","display_name":"Singlet molecular oxygen","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Rose bengal plus 540-nm light; up to 100 mM KI; microbial assays and a mouse skin-abrasion model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Local photochemical system, not an effect of oral KI alone. Peroxyiodide intermediates were proposed, not directly established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"KI amplified an externally activated antimicrobial reaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Potassium Iodide Potentiates Antimicrobial Photodynamic Inactivation Mediated by Rose Bengal in In Vitro and In Vivo Studies. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28438946/ · DOI 10.1128/aac.00467-17","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ec6fc55e-fd3c-5aae-abb9-644c44964647","evidence_kind":"source_excerpt","locator":"Lines 312-318","start_line":312,"end_line":318,"excerpt":"## ki-pdt-killing\nKI amplified an externally activated antimicrobial reaction.\nKI increased light/Rose-bengal killing by up to six logs in the tested bacterial and Candida systems.\nModel: Rose bengal plus 540-nm light; up to 100 mM KI; microbial assays and a mouse skin-abrasion model.\nLimitations: Local photochemical system, not an effect of oral KI alone. Peroxyiodide intermediates were proposed, not directly established.\nEvidence location: Primary abstract\nPotassium Iodide Potentiates Antimicrobial Photodynamic Inactivation Mediated by Rose Bengal in In Vitro and In Vivo Studies. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28438946/ · DOI 10.1128/aac.00467-17","model_system":"Rose bengal plus 540-nm light; up to 100 mM KI; microbial assays and a mouse skin-abrasion model.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. 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