{"id":"808e26c8-a413-5dfd-a207-5ac9a685fc73","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-gabaa-knockout","predicate":"alpha4_loss_blocks","statement":"Taurine-evoked currents were absent in relay neurons from GABA-A-receptor alpha4-subunit knockout mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9f5e4fef-1a15-59c2-a234-04dfba78615a","mechanism_event_label":"Removing a receptor subunit tested dependence of the current.","subject":{"id":"04a65277-f6fc-51c4-85e8-6de07891530c","slug":"mouse-gabaa-alpha4beta2delta","display_name":"Mouse extrasynaptic alpha4beta2delta GABA-A receptor","entity_type_key":"protein_complex"},"object":{"id":"e4e96d25-dc16-5b20-8f7c-e1bfbb55ea82","slug":"mouse-taurine-tonic-inhibition","display_name":"Mouse thalamic taurine-evoked tonic inhibition","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9f5e4fef-1a15-59c2-a234-04dfba78615a","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-gabaa-knockout-event","event_type":"observed_relationship","label":"Removing a receptor subunit tested dependence of the current.","description":"Taurine-evoked currents were absent in relay neurons from GABA-A-receptor alpha4-subunit knockout mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"04a65277-f6fc-51c4-85e8-6de07891530c","slug":"mouse-gabaa-alpha4beta2delta","display_name":"Mouse extrasynaptic alpha4beta2delta GABA-A receptor","entity_type_key":"protein_complex"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e4e96d25-dc16-5b20-8f7c-e1bfbb55ea82","slug":"mouse-taurine-tonic-inhibition","display_name":"Mouse thalamic taurine-evoked tonic inhibition","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse alpha4-knockout thalamic neuron recordings.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Subunit dependence is local to this experimental response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Removing a receptor subunit tested dependence of the current.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18171928/ · DOI 10.1523/JNEUROSCI.3996-07.2008","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4d9b176b-4afc-5915-b9f5-b94ee6161076","evidence_kind":"source_excerpt","locator":"Lines 441-447","start_line":441,"end_line":447,"excerpt":"## taurine-gabaa-knockout\nRemoving a receptor subunit tested dependence of the current.\nTaurine-evoked currents were absent in relay neurons from GABA-A-receptor alpha4-subunit knockout mice.\nModel: Mouse alpha4-knockout thalamic neuron recordings.\nLimitations: Subunit dependence is local to this experimental response.\nEvidence access: Primary abstract\nTaurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18171928/ · DOI 10.1523/JNEUROSCI.3996-07.2008","model_system":"Mouse alpha4-knockout thalamic neuron recordings.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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