{"id":"8081e872-fbb4-54af-8ab4-b263ae7803ca","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-sig-smrt-repression","predicate":"represses","statement":"SMRT associated with retinoid receptors and mediated transcriptional silencing in engineered assays.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"5850c3fb-adeb-547d-b571-30ab35add32e","mechanism_event_label":"Corepressor proteins help keep selected receptor-controlled genes quiet.","subject":{"id":"84741ea0-69f3-5fcc-8b8a-fa1d0572beb2","slug":"ncor2","display_name":"Nuclear receptor corepressor 2 / SMRT","entity_type_key":"protein"},"object":{"id":"6c127d6b-61f1-5b4e-a608-3d1aa94296de","slug":"ra-responsive-transcription","display_name":"Retinoic-acid-responsive transcription","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5850c3fb-adeb-547d-b571-30ab35add32e","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-sig-smrt-repression-event","event_type":"biochemical_relationship","label":"Corepressor proteins help keep selected receptor-controlled genes quiet.","description":"SMRT associated with retinoid receptors and mediated transcriptional silencing in engineered assays.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"nutrient-context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0453bf0c-3c7c-5275-9b9e-8d7f01613b51","slug":"rar-family","display_name":"Retinoic acid receptor family","entity_type_key":"protein_family"},"role":"receptor-context","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"84741ea0-69f3-5fcc-8b8a-fa1d0572beb2","slug":"ncor2","display_name":"Nuclear receptor corepressor 2 / SMRT","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6c127d6b-61f1-5b4e-a608-3d1aa94296de","slug":"ra-responsive-transcription","display_name":"Retinoic-acid-responsive transcription","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_locator","value_text":"Abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Biochemical interactions and engineered cellular transcription reporters.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Unliganded receptor and SMRT","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a claim that all unliganded RAR targets are repressed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Biochemical and cellular reporter systems","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Corepressor proteins help keep selected receptor-controlled genes quiet.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[va-chen-1995] A transcriptional co-repressor that interacts with nuclear hormone receptors (1995). https://pubmed.ncbi.nlm.nih.gov/7566127/ DOI: 10.1038/377454a0","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Receptor complexes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7da592b8-5806-51fa-92ce-1934212ea3a6","evidence_kind":"source_excerpt","locator":"Lines 1136-1147","start_line":1136,"end_line":1147,"excerpt":"### va-sig-smrt-repression\nSMRT associated with retinoid receptors and mediated transcriptional silencing in engineered assays.\nCondition category: normal\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Corepressor proteins help keep selected receptor-controlled genes quiet.\norganism: Biochemical and cellular reporter systems\ntissue_or_cell_type: Receptor complexes\nexperimental_model: Biochemical interactions and engineered cellular transcription reporters.\nlimitations: Not a claim that all unliganded RAR targets are repressed.\nevidence_locator: Abstract\nexposure: Unliganded receptor and SMRT\n[va-chen-1995] A transcriptional co-repressor that interacts with nuclear hormone receptors (1995). https://pubmed.ncbi.nlm.nih.gov/7566127/ DOI: 10.1038/377454a0","model_system":"Biochemical interactions and engineered cellular transcription reporters.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [va-chen-1995] A transcriptional co-repressor that interacts with nuclear hormone receptors (1995). https://pubmed.ncbi.nlm.nih.gov/7566127/ DOI: 10.1038/377454a0","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}