{"id":"80670e0f-cffd-5a49-bf05-dcb62e576b6b","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-pparg-coactivator","predicate":"changes","statement":"Astaxanthin enhanced PPAR-gamma recruitment of TIF2 and SRC-1 but not CBP, and opposed rosiglitazone-induced CBP recruitment in the reported assays.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bc52bd1c-661c-594d-8e54-beb9f1ccb8dc","mechanism_event_label":"The receptor recruited different transcriptional partners.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"2dcaca84-b17d-51f5-9b8a-6c0665aee94f","slug":"astaxanthin-pparg-coactivator-assay","display_name":"PPAR gamma coactivator assay preparation; species unresolved","entity_type_key":"protein_state"},"evidence_count":1,"mechanism_event":{"id":"bc52bd1c-661c-594d-8e54-beb9f1ccb8dc","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-pparg-coactivator-event","event_type":"observed_relationship","label":"The receptor recruited different transcriptional partners.","description":"Astaxanthin enhanced PPAR-gamma recruitment of TIF2 and SRC-1 but not CBP, and opposed rosiglitazone-induced CBP recruitment in the reported assays.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2dcaca84-b17d-51f5-9b8a-6c0665aee94f","slug":"astaxanthin-pparg-coactivator-assay","display_name":"PPAR gamma coactivator assay preparation; species unresolved","entity_type_key":"protein_state"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Binding/coactivator assays; receptor-construct species not resolved from the accessed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Assay preparation is retained separately from canonical species-specific receptor nodes; this is not a proven drug interaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The receptor recruited different transcriptional partners.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Astaxanthin functions differently as a selective peroxisome proliferator-activated receptor γ modulator in adipocytes and macrophages. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22732454/ · DOI 10.1016/j.bcp.2012.05.021","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d0440df5-2a07-5e4f-9809-c84e8054c4ab","evidence_kind":"source_excerpt","locator":"Lines 270-276","start_line":270,"end_line":276,"excerpt":"## astaxanthin-pparg-coactivator\nThe receptor recruited different transcriptional partners.\nAstaxanthin enhanced PPAR-gamma recruitment of TIF2 and SRC-1 but not CBP, and opposed rosiglitazone-induced CBP recruitment in the reported assays.\nModel: Binding/coactivator assays; receptor-construct species not resolved from the accessed abstract.\nLimitations: Assay preparation is retained separately from canonical species-specific receptor nodes; this is not a proven drug interaction.\nEvidence access: Primary abstract\nAstaxanthin functions differently as a selective peroxisome proliferator-activated receptor γ modulator in adipocytes and macrophages. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22732454/ · DOI 10.1016/j.bcp.2012.05.021","model_system":"Binding/coactivator assays; receptor-construct species not resolved from the accessed abstract.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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