{"id":"8023db6c-48cb-59bb-bbbe-a310a1535d4e","stable_key":"cea4b417-bb71-5d5d-8fe1-4e175aca750c:graviola-juice-composition","predicate":"contains","statement":"The commercial Annona muricata juice used in the chronic mouse study contained 16.2 mg/L annonacin plus other acetogenins and 41 measured isoquinoline alkaloids.","claim_class":"identity","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"e7295de5-fa0a-5adc-9b8a-18a9f76fa8d3","mechanism_event_label":"The commercial Annona muricata juice used in the chronic mouse study contained 16.2 mg/L annonacin plus other acetogenins and 41 measured isoquinoline alkaloids.","subject":{"id":"a80086e7-d7cd-5487-b9ab-7ece7e008c12","slug":"commercial-soursop-juice-2016","display_name":"Commercial soursop juice used in the 2016 chronic mouse study","entity_type_key":"botanical"},"object":{"id":"46b657b6-1692-59cb-bccd-e94db35a2734","slug":"annonacin","display_name":"Annonacin","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"e7295de5-fa0a-5adc-9b8a-18a9f76fa8d3","stable_key":"cea4b417-bb71-5d5d-8fe1-4e175aca750c:graviola-juice-composition-event","event_type":"observed_relationship","label":"The commercial Annona muricata juice used in the chronic mouse study contained 16.2 mg/L annonacin plus other acetogenins and 41 measured isoquinoline alkaloids.","description":"The commercial Annona muricata juice used in the chronic mouse study contained 16.2 mg/L annonacin plus other acetogenins and 41 measured isoquinoline alkaloids.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a80086e7-d7cd-5487-b9ab-7ece7e008c12","slug":"commercial-soursop-juice-2016","display_name":"Commercial soursop juice used in the 2016 chronic mouse study","entity_type_key":"botanical"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"46b657b6-1692-59cb-bccd-e94db35a2734","slug":"annonacin","display_name":"Annonacin","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fc85953a-bdac-5e14-b64f-7e2ce9775a04","slug":"graviola","display_name":"Graviola / Annona muricata","entity_type_key":"botanical"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Study juice provided as drinking fluid","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Juice lot used for 12-month exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Analyzed commercial soursop juice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"One product lot does not define every fruit, juice, leaf tea or supplement; the mixture contained many candidate actors.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Graviola (Annona muricata) chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"graviola","display_name":"Graviola / Annona muricata","entity_type_key":"botanical"}},{"dimension":"organism","value_text":"Analyzed commercial soursop juice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The commercial Annona muricata juice used in the chronic mouse study contained 16.2 mg/L annonacin plus other acetogenins and 41 measured isoquinoline alkaloids.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Chronic consumption of Annona muricata juice triggers and aggravates cerebral tau phosphorylation in wild-type and MAPT transgenic mice. (2016). https://pubmed.ncbi.nlm.nih.gov/27569447/ DOI: 10.1111/jnc.13835","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Food-composition analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"HPLC-MS constituent analysis","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a5f36606-a1d8-503d-ad1c-ba28eadcb9c0","evidence_kind":"source_excerpt","locator":"Lines 11-20","start_line":11,"end_line":20,"excerpt":"## graviola-juice-composition\nThe commercial Annona muricata juice used in the chronic mouse study contained 16.2 mg/L annonacin plus other acetogenins and 41 measured isoquinoline alkaloids.\nModel/species: Analyzed commercial soursop juice\nTissue/system: HPLC-MS constituent analysis\nExposure: Study juice provided as drinking fluid\nRoute: Food-composition analysis\nDuration: Juice lot used for 12-month exposure\nLimits: One product lot does not define every fruit, juice, leaf tea or supplement; the mixture contained many candidate actors.\nPrimary reference: Chronic consumption of Annona muricata juice triggers and aggravates cerebral tau phosphorylation in wild-type and MAPT transgenic mice. (2016). https://pubmed.ncbi.nlm.nih.gov/27569447/ DOI: 10.1111/jnc.13835\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Analyzed commercial soursop juice","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dde73deb-4328-5cc7-aa41-04b7d845f4fa","stable_key":"import-cea4b417-bb71-5d5d-8fe1-4e175aca750c","title":"Graviola (Annona muricata): mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"7922ecd3e96739207a7b7b767477da7acf16b0ad177e4d5f9b41dc5606812304","revision_id":"a18d124d-a45d-57d5-8264-29818c1e1a07","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}