{"id":"80003181-9215-53a1-a634-87aa98939291","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-partial-rescue","predicate":"rescues","statement":"BRL co-treatment rescued FABP4, LPL and perilipin transcripts but did not prevent reduced GLUT4, glucose uptake or triglyceride content.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6fc001e3-8c96-593b-8955-5124eb3d5afa","mechanism_event_label":"Restoring some target genes did not restore the whole response.","subject":{"id":"8d369052-c2cd-5806-96c9-247cad7e13af","slug":"rosiglitazone","display_name":"Rosiglitazone / BRL49653","entity_type_key":"small_molecule"},"object":{"id":"b42d00fd-2d96-5590-882c-24c5a7c584ee","slug":"human-adipocyte-pparg-target-transcripts","display_name":"Human adipocyte PPAR-gamma target transcripts","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6fc001e3-8c96-593b-8955-5124eb3d5afa","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-partial-rescue-event","event_type":"observed_relationship","label":"Restoring some target genes did not restore the whole response.","description":"BRL co-treatment rescued FABP4, LPL and perilipin transcripts but did not prevent reduced GLUT4, glucose uptake or triglyceride content.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8d369052-c2cd-5806-96c9-247cad7e13af","slug":"rosiglitazone","display_name":"Rosiglitazone / BRL49653","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b42d00fd-2d96-5590-882c-24c5a7c584ee","slug":"human-adipocyte-pparg-target-transcripts","display_name":"Human adipocyte PPAR-gamma target transcripts","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7f456e18-fabc-532d-bbfe-cd3a8cf1b348","slug":"pparg","display_name":"Human PPAR gamma / PPARG","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9f91e4bd-a060-5039-9570-6c33d366fb2d","slug":"fabp4","display_name":"Human fatty acid-binding protein 4 / FABP4","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"c7c75440-849d-54b5-baaf-2616210143da","slug":"lpl","display_name":"Human lipoprotein lipase / LPL","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"39c80f3a-565d-5b2e-b04c-5735b0347db7","slug":"plin1","display_name":"Human perilipin 1 / PLIN1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""},{"entity":{"id":"0b58e90f-c976-5f65-82e5-8735455b9094","slug":"slc2a4","display_name":"Human glucose transporter 4 / SLC2A4","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":6,"notes":""},{"entity":{"id":"8a82839e-e5de-5ed9-8d0d-a71ae8652e66","slug":"human-adipocyte-triglyceride-content","display_name":"Human adipocyte triglyceride content","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":7,"notes":""},{"entity":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":8,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"One-week co-treatment of primary human adipocyte cultures.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Transcript rescue did not restore all downstream functions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Restoring some target genes did not restore the whole response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Trans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytes. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18287349/ · DOI 10.1093/jn/138.3.455","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f33d24d6-c677-5c0e-9008-89352fa7c692","evidence_kind":"source_excerpt","locator":"Lines 118-124","start_line":118,"end_line":124,"excerpt":"## cla-partial-rescue\nRestoring some target genes did not restore the whole response.\nBRL co-treatment rescued FABP4, LPL and perilipin transcripts but did not prevent reduced GLUT4, glucose uptake or triglyceride content.\nModel: One-week co-treatment of primary human adipocyte cultures.\nLimitations: Transcript rescue did not restore all downstream functions.\nEvidence access: Primary abstract\nTrans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytes. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18287349/ · DOI 10.1093/jn/138.3.455","model_system":"One-week co-treatment of primary human adipocyte cultures.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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