{"id":"7feb94af-b171-58a1-a523-a06c46d79c65","stable_key":"research:selenom-supports-thioredoxin-activity","predicate":"supports","statement":"SELENOM perturbations changed thioredoxin activity, with loss reducing the measured activity.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"literature_reviewed:direct_experimental","direction":"positive","is_public":true,"mechanism_event_id":"2a7b3731-db90-5a1e-a7d0-de37724423e2","mechanism_event_label":"SELENOM supported a cellular thioredoxin activity readout.","subject":{"id":"7ba3791b-64d4-5a98-b084-03eef281b738","slug":"selenom","display_name":"SELENOM","entity_type_key":"protein"},"object":{"id":"7f389151-dcd3-500e-9a1d-0034a34550df","slug":"thioredoxin-activity","display_name":"Thioredoxin reductive activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2a7b3731-db90-5a1e-a7d0-de37724423e2","stable_key":"research:selenom-supports-thioredoxin-activity","event_type":"genetic-perturbation","label":"SELENOM supported a cellular thioredoxin activity readout.","description":"SELENOM perturbations changed thioredoxin activity, with loss reducing the measured activity.","status":"active","compartment":null,"participants":[{"entity":{"id":"7ba3791b-64d4-5a98-b084-03eef281b738","slug":"selenom","display_name":"SELENOM","entity_type_key":"protein"},"role":"perturbed-protein","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7f389151-dcd3-500e-9a1d-0034a34550df","slug":"thioredoxin-activity","display_name":"Thioredoxin reductive activity","entity_type_key":"cellular_process"},"role":"measured-process","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cell_type","value_text":"hypothalamic cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Loss and expression experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The direct SELENOM substrate was not established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"mouse","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"acba1623-44fd-5e31-8379-fecb778a4d10","evidence_kind":"curated_literature_summary","locator":"lines 798-808","start_line":798,"end_line":808,"excerpt":"## selenom-supports-thioredoxin-activity\n\nSELENOM supported a cellular thioredoxin activity readout.\n\nSELENOM perturbations changed thioredoxin activity, with loss reducing the measured activity.\n\nOrganism: mouse\nCell type: hypothalamic cells\nExperimental model: Loss and expression experiments\nLimitations: The direct SELENOM substrate was not established.\nPrimary reference: [Selenoprotein M Promotes Hypothalamic Leptin Signaling and Thioredoxin Antioxidant Activity](https://pmc.ncbi.nlm.nih.gov/articles/PMC8617589/)","model_system":"Loss and expression experiments","directness":"author_interpretation","verification_status":"secondary_verified","notes":"Curated summary; inspect the linked primary papers for original methods and results.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f892f13-06ea-5199-a33c-a703f35c80ae","stable_key":"selenium-research-2026-09-17","title":"Selenium: literature corrections and mechanism additions","document_type":"curated_literature_review","citation_label":"Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually","file_path":"","sha256":"0b818b10c1c7120e5caf7f4d4019d7bd025d745692e424f515d3ef903c9ab7f3","revision_id":"80984e03-5f0f-5877-8094-afef7637444e","review_status":"secondary_verified","notes":"Secondary curated summaries of primary experiments, with explicit models and limitations. Not archived primary full text."}}],"relations":[],"conflicts":[],"corrections":[],"research":{"topic":"hypothalamic-redox","plain_language":"SELENOM supported a cellular thioredoxin activity readout.","evidence_scope":"direct_experimental","papers":[{"key":"gong-2019-selenom-leptin","title":"Selenoprotein M Promotes Hypothalamic Leptin Signaling and Thioredoxin Antioxidant Activity","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8617589/","doi":"10.1089/ars.2018.7594","year":2019,"model":"Mouse knockout and mHypoE-44 hypothalamic-cell perturbations","summary":"Tests SELENOM effects on leptin-responsive signaling and thioredoxin activity."}]}}