{"id":"7fd718ed-aabc-5b21-ace2-741c05f7cd77","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:renal-hyperpolarization-rescues-mg-after-k-depletion","predicate":"hyperpolarization-restores","statement":"Thiocyanate-induced hyperpolarization restored Mg2+ uptake in potassium-depleted MDCT cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"d527abdc-3ef0-5479-afb0-d720b37acb1d","mechanism_event_label":"Restoring the electrical driving force helped magnesium enter despite prior potassium depletion.","subject":{"id":"fba9caf6-526d-55ba-895e-0c9878c864ea","slug":"dct-membrane-potential","display_name":"DCT membrane potential","entity_type_key":"cellular_process"},"object":{"id":"2c31af15-4eba-5fdc-9a37-11104bd19c82","slug":"cellular-magnesium-influx","display_name":"Cellular magnesium influx","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d527abdc-3ef0-5479-afb0-d720b37acb1d","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:renal-hyperpolarization-rescues-mg-after-k-depletion-event","event_type":"biochemical_relationship","label":"Restoring the electrical driving force helped magnesium enter despite prior potassium depletion.","description":"Thiocyanate-induced hyperpolarization restored Mg2+ uptake in potassium-depleted MDCT cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fba9caf6-526d-55ba-895e-0c9878c864ea","slug":"dct-membrane-potential","display_name":"DCT membrane potential","entity_type_key":"cellular_process"},"role":"causal-subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2c31af15-4eba-5fdc-9a37-11104bd19c82","slug":"cellular-magnesium-influx","display_name":"Cellular magnesium influx","entity_type_key":"cellular_process"},"role":"measured-target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5d54e0a3-869f-5132-82c9-4c0ff47cd400","slug":"thiocyanate-ion","display_name":"Thiocyanate ion","entity_type_key":"ion"},"role":"experimental-agent","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"transported-ion","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"depleted-ion","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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