{"id":"7fc922f7-05eb-5be5-b5e7-a47a70737efa","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-pantethine-ldl-2011","predicate":"reduces","statement":"At 16 weeks, the pantethine trial reported a 4 mg/dL (4%) LDL-C reduction from baseline, with a significant comparison against placebo while both groups followed the TLC diet.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"ac60b4ff-f2d9-5adc-aa18-0449a4d24afb","mechanism_event_label":"Pantethine produced a modest LDL reduction in this trial.","subject":{"id":"c0600873-c581-5429-91cb-414f179823ce","slug":"pantethine","display_name":"Pantethine","entity_type_key":"small_molecule"},"object":{"id":"ac5f5914-4824-5f9b-93c7-a6b5a52b53af","slug":"ldl-cholesterol-concentration","display_name":"LDL cholesterol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ac60b4ff-f2d9-5adc-aa18-0449a4d24afb","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-pantethine-ldl-2011-event","event_type":"observed_intervention","label":"Pantethine produced a modest LDL reduction in this trial.","description":"At 16 weeks, the pantethine trial reported a 4 mg/dL (4%) LDL-C reduction from baseline, with a significant comparison against placebo while both groups followed the TLC diet.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c0600873-c581-5429-91cb-414f179823ce","slug":"pantethine","display_name":"Pantethine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ac5f5914-4824-5f9b-93c7-a6b5a52b53af","slug":"ldl-cholesterol-concentration","display_name":"LDL cholesterol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized triple-blind placebo-controlled 16-week trial in 120 adults at low-to-moderate cardiovascular risk","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"TLC diet begun four weeks before randomization and continued; 60 per group; pantethine 600 mg/day for weeks 1–8 and 900 mg/day for weeks 9–16.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Lipid markers rather than cardiovascular events; pantethine is a derivative, not dietary B5 repletion. Absolute changes were small. Industry-associated authors; full methods were not retrieved. The 4 mg/dL figure is the reported change from baseline, not a separately verified adjusted between-group estimate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Pantethine produced a modest LDL reduction in this trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-clin-rumberger2011] Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. (2011). https://pubmed.ncbi.nlm.nih.gov/21925346/ DOI: 10.1016/j.nutres.2011.08.001","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Circulating lipids and lipoproteins","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9978247d-0f39-520a-bb3d-2cc859578dcd","evidence_kind":"source_excerpt","locator":"Lines 1383-1395","start_line":1383,"end_line":1395,"excerpt":"### b5-clin-pantethine-ldl-2011\nAt 16 weeks, the pantethine trial reported a 4 mg/dL (4%) LDL-C reduction from baseline, with a significant comparison against placebo while both groups followed the TLC diet.\nCondition category: normal\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Pantethine produced a modest LDL reduction in this trial.\norganism: Homo sapiens\ntissue_or_cell_type: Circulating lipids and lipoproteins\nexperimental_model: Randomized triple-blind placebo-controlled 16-week trial in 120 adults at low-to-moderate cardiovascular risk\nlimitations: Lipid markers rather than cardiovascular events; pantethine is a derivative, not dietary B5 repletion. Absolute changes were small. Industry-associated authors; full methods were not retrieved. The 4 mg/dL figure is the reported change from baseline, not a separately verified adjusted between-group estimate.\nexposure: TLC diet begun four weeks before randomization and continued; 60 per group; pantethine 600 mg/day for weeks 1–8 and 900 mg/day for weeks 9–16.\ncross_nutrient: false\nevidence_location: Primary indexed abstract.\n[b5-clin-rumberger2011] Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. 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