{"id":"7fc4985f-614d-55a1-9a96-0019b8b08782","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-electron-acceptor-growth","predicate":"supports","statement":"The mouse experiments linked increased luminal respiratory electron acceptors to expansion of Escherichia and Salmonella when the PPAR-gamma homeostatic pathway was disrupted.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"63e63ea4-7f67-51a9-b9a6-b41d7c80ccde","mechanism_event_label":"Host metabolism changed which bacteria could expand.","subject":{"id":"e4a04b78-1047-5ea7-b461-83860bb2de65","slug":"mouse-luminal-nitrate","display_name":"Mouse colonic luminal nitrate availability","entity_type_key":"cellular_process"},"object":{"id":"17bf10bf-1e97-58dc-a7f2-edc43cccb33b","slug":"mouse-enterobacteriaceae-expansion","display_name":"Mouse colonic Enterobacteriaceae expansion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"63e63ea4-7f67-51a9-b9a6-b41d7c80ccde","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-electron-acceptor-growth-event","event_type":"observed_relationship","label":"Host metabolism changed which bacteria could expand.","description":"The mouse experiments linked increased luminal respiratory electron acceptors to expansion of Escherichia and Salmonella when the PPAR-gamma homeostatic pathway was disrupted.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e4a04b78-1047-5ea7-b461-83860bb2de65","slug":"mouse-luminal-nitrate","display_name":"Mouse colonic luminal nitrate availability","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"17bf10bf-1e97-58dc-a7f2-edc43cccb33b","slug":"mouse-enterobacteriaceae-expansion","display_name":"Mouse colonic Enterobacteriaceae expansion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"44d55fd2-bde7-5bd1-91cd-c751ef642356","slug":"mouse-colonic-epithelial-oxygen-use","display_name":"Mouse colonic epithelial oxygen consumption","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8e9622fd-f3a4-526b-9ab5-7389d768d937","slug":"mouse-pparg","display_name":"Mouse peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse microbiota perturbation and bacterial respiration experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The pathway is not a universal explanation for every case of dysbiosis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Host metabolism changed which bacteria could expand.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28798125/ · DOI 10.1126/science.aam9949","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"805f9e77-40b8-59ee-bcc0-899140a85ed7","evidence_kind":"source_excerpt","locator":"Lines 230-236","start_line":230,"end_line":236,"excerpt":"## butyrate-electron-acceptor-growth\nHost metabolism changed which bacteria could expand.\nThe mouse experiments linked increased luminal respiratory electron acceptors to expansion of Escherichia and Salmonella when the PPAR-gamma homeostatic pathway was disrupted.\nModel: Mouse microbiota perturbation and bacterial respiration experiments.\nLimitations: The pathway is not a universal explanation for every case of dysbiosis.\nEvidence access: Primary abstract\nMicrobiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28798125/ · DOI 10.1126/science.aam9949","model_system":"Mouse microbiota perturbation and bacterial respiration experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"33205bb8-dcbe-5d2c-afca-86075d7748d1","stable_key":"import-104835a3-b891-5dc4-a6bb-42ab7c6f96c4","title":"Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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