{"id":"7fb67141-76c5-59cc-aa1a-2f92ffe3192c","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-chick-growth-plate","predicate":"associated_with","statement":"Growth-plate histology suggested enhanced maturation with boron supplementation in the chick feeding experiment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8926f002-9c7e-5d8f-88a0-b986b6c0bba4","mechanism_event_label":"The developing growth plate appeared to mature differently; this is an animal histology finding.","subject":{"id":"56db2f3c-f247-573f-bb7c-47cac02ea60f","slug":"boric-acid","display_name":"Boric acid / orthoboric acid / B(OH)3","entity_type_key":"small_molecule"},"object":{"id":"6ced87d3-f432-536a-b1d7-82e2e65c4bf2","slug":"growth-plate-maturation","display_name":"Growth plate maturation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8926f002-9c7e-5d8f-88a0-b986b6c0bba4","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-chick-growth-plate-event","event_type":"observed_intervention","label":"The developing growth plate appeared to mature differently; this is an animal histology finding.","description":"Growth-plate histology suggested enhanced maturation with boron supplementation in the chick feeding experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"role":"dietary_context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"56db2f3c-f247-573f-bb7c-47cac02ea60f","slug":"boric-acid","display_name":"Boric acid / orthoboric acid / B(OH)3","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6ced87d3-f432-536a-b1d7-82e2e65c4bf2","slug":"growth-plate-maturation","display_name":"Growth plate maturation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/8140930.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6f8776234acbd0efd282761bbbcb0f51b39d8882c651b3f64686a890f646d4fc\", \"start_char\": 0, \"end_char\": 1621, \"text_sha256\": \"6f8776234acbd0efd282761bbbcb0f51b39d8882c651b3f64686a890f646d4fc\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Factorial boron/vitamin-D3 feeding experiment in chicks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"26 days; basal boron ≤0.18 mg/kg with 0 or 1.4 mg/kg orthoboric acid supplement; vitamin D3 3.13 or 15.6 µg/kg","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Animal developmental experiment. It did not demonstrate direct CYP24A1 inhibition or that boron replaces vitamin D in humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Day-old cockerel chicks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The developing growth plate appeared to mature differently; this is an animal histology finding.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p8140930] Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. (1994). https://pubmed.ncbi.nlm.nih.gov/8140930/ DOI: 10.1002/jbmr.5650090206","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma metabolism and growth plates","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"efecc6a8-11b5-58b5-9b6e-66cfc95a29e3","evidence_kind":"source_excerpt","locator":"Lines 872-883","start_line":872,"end_line":883,"excerpt":"### boron-chick-growth-plate\nGrowth-plate histology suggested enhanced maturation with boron supplementation in the chick feeding experiment.\nCondition category: normal\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The developing growth plate appeared to mature differently; this is an animal histology finding.\norganism: Day-old cockerel chicks\ntissue_or_cell_type: Plasma metabolism and growth plates\nexperimental_model: Factorial boron/vitamin-D3 feeding experiment in chicks\nlimitations: Animal developmental experiment. It did not demonstrate direct CYP24A1 inhibition or that boron replaces vitamin D in humans.\nexposure: 26 days; basal boron ≤0.18 mg/kg with 0 or 1.4 mg/kg orthoboric acid supplement; vitamin D3 3.13 or 15.6 µg/kg\nevidence_span: {\"source_cache\": \"artifacts/boron-research/8140930.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6f8776234acbd0efd282761bbbcb0f51b39d8882c651b3f64686a890f646d4fc\", \"start_char\": 0, \"end_char\": 1621, \"text_sha256\": \"6f8776234acbd0efd282761bbbcb0f51b39d8882c651b3f64686a890f646d4fc\"}\n[boron-p8140930] Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. (1994). https://pubmed.ncbi.nlm.nih.gov/8140930/ DOI: 10.1002/jbmr.5650090206","model_system":"Factorial boron/vitamin-D3 feeding experiment in chicks","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [boron-p8140930] Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. (1994). https://pubmed.ncbi.nlm.nih.gov/8140930/ DOI: 10.1002/jbmr.5650090206","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2d96c547-aeec-5d8b-9d31-1288da209f89","stable_key":"import-7edf94bb-95c8-5234-9161-9eb338bb9b36","title":"Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"0a32c1c5c70cfb4a378f6ace35cf5b75d90ed3065ada91b9f9f64015d603c8e3","revision_id":"38f316f2-4344-542e-a638-0ac5402f678d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}