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Recorded because a mechanism record should not be filtered for favourable outcomes.\nexposure: Metformin and other AMPK activators with FXR agonists\nevidence_span: {\"source_cache\": \"artifacts/metformin-research/24531544.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9e34abf954452e017d254058f7e611697560bba87a53cf726c88f0b77d6673ad\", \"start_char\": 0, \"end_char\": 1358, \"text_sha256\": \"9e34abf954452e017d254058f7e611697560bba87a53cf726c88f0b77d6673ad\"}\n[metformin-p24531544] Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk. (2014). https://pubmed.ncbi.nlm.nih.gov/24531544/ DOI: 10.1172/jci68815","model_system":"Mass-spectrometry interaction screen in human hepatoma cells with mouse liver, intestine and a cholestasis model","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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