{"id":"7faa4f1a-65d6-529a-8222-43f78a7095aa","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-sperm-count","predicate":"increased","statement":"The trial reported improved total sperm count, remaining significant after adjustment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0658fe02-2490-5aae-a965-9eda20a5bf4d","mechanism_event_label":"A semen measurement improved; this does not establish better pregnancy or live-birth rates.","subject":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"object":{"id":"61787419-24de-5dcb-a3ae-afdaa09f73a9","slug":"semen-total-sperm-count","display_name":"Total sperm count per ejaculate","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0658fe02-2490-5aae-a965-9eda20a5bf4d","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-sperm-count-event","event_type":"biochemical_relationship","label":"A semen measurement improved; this does not establish better pregnancy or live-birth rates.","description":"The trial reported improved total sperm count, remaining significant after adjustment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"61787419-24de-5dcb-a3ae-afdaa09f73a9","slug":"semen-total-sperm-count","display_name":"Total sperm count per ejaculate","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/31468596.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"43f86ccba4712a72d13292bf7fea87e9feb0c514ff5bebcd79adf94f656522c4\", \"start_char\": 0, \"end_char\": 1442, \"text_sha256\": \"43f86ccba4712a72d13292bf7fea87e9feb0c514ff5bebcd79adf94f656522c4\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"25 mg/day lycopene for 12 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small trial; distinguish between-group adjusted results from numerous within-group changes; no live-birth outcome established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human, 44 men with oligozoospermia","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A semen measurement improved; this does not establish better pregnancy or live-birth rates.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p31468596] The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double-blind, placebo-controlled clinical trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31468596/ DOI: 10.1002/ptr.6493","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Semen analysis","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0f317d74-5890-51d1-ab11-3e27524a08e8","evidence_kind":"source_excerpt","locator":"Lines 1248-1259","start_line":1248,"end_line":1259,"excerpt":"### lycopene-sperm-count\nThe trial reported improved total sperm count, remaining significant after adjustment.\nCondition category: normal\nnutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A semen measurement improved; this does not establish better pregnancy or live-birth rates.\norganism: Human, 44 men with oligozoospermia\ntissue_or_cell_type: Semen analysis\nexperimental_model: Double-blind placebo-controlled trial\nlimitations: Small trial; distinguish between-group adjusted results from numerous within-group changes; no live-birth outcome established.\nexposure: 25 mg/day lycopene for 12 weeks\nevidence_span: {\"source_cache\": \"artifacts/lycopene-research/31468596.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"43f86ccba4712a72d13292bf7fea87e9feb0c514ff5bebcd79adf94f656522c4\", \"start_char\": 0, \"end_char\": 1442, \"text_sha256\": \"43f86ccba4712a72d13292bf7fea87e9feb0c514ff5bebcd79adf94f656522c4\"}\n[lycopene-p31468596] The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double-blind, placebo-controlled clinical trial. 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