{"id":"7f1ed80c-3d7e-534f-8a62-00f7a7c44794","stable_key":"cb41aa31-e26b-5b60-b7e0-e4985fb7aea8:hydroxytyrosol-supplement-metabolites","predicate":"is_metabolized_to","statement":"After single olive-derived supplement doses, homovanillic acid, hydroxytyrosol-3-O-sulfate and DOPAC were major plasma and urine metabolites, with plasma peaks at about 30 minutes.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"c9de6ee0-e9bb-5b61-870b-4f6c03f304d3","mechanism_event_label":"After single olive-derived supplement doses, homovanillic acid, hydroxytyrosol-3-O-sulfate and DOPAC were major plasma and urine metabolites, with plasma peaks at about 30 minutes.","subject":{"id":"45a7aaec-8acc-5d5a-a014-c483ef5385e2","slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"},"object":{"id":"2aa4e9c1-41c1-5ec9-9f85-535d7d181dbc","slug":"hydroxytyrosol-major-human-metabolites","display_name":"Homovanillic acid, hydroxytyrosol-3-O-sulfate and DOPAC","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"c9de6ee0-e9bb-5b61-870b-4f6c03f304d3","stable_key":"cb41aa31-e26b-5b60-b7e0-e4985fb7aea8:hydroxytyrosol-supplement-metabolites-event","event_type":"observed_relationship","label":"After single olive-derived supplement doses, homovanillic acid, hydroxytyrosol-3-O-sulfate and DOPAC were major plasma and urine metabolites, with plasma peaks at about 30 minutes.","description":"After single olive-derived supplement doses, homovanillic acid, hydroxytyrosol-3-O-sulfate and DOPAC were major plasma and urine metabolites, with plasma peaks at about 30 minutes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"45a7aaec-8acc-5d5a-a014-c483ef5385e2","slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2aa4e9c1-41c1-5ec9-9f85-535d7d181dbc","slug":"hydroxytyrosol-major-human-metabolites","display_name":"Homovanillic acid, hydroxytyrosol-3-O-sulfate and DOPAC","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"30.58 or 61.48 mg hydroxytyrosol supplement; fortified olive-oil control","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"0.5-12 hours","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twelve healthy volunteers in a randomized blinded crossover study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Higher bioavailability is a prerequisite, not proof of cardiovascular protection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hydroxytyrosol chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Twelve healthy volunteers in a randomized blinded crossover study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"After single olive-derived supplement doses, homovanillic acid, hydroxytyrosol-3-O-sulfate and DOPAC were major plasma and urine metabolites, with plasma peaks at about 30 minutes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Oral Bioavailability and Metabolism of Hydroxytyrosol from Food Supplements. (2023). https://pubmed.ncbi.nlm.nih.gov/36678196/ DOI: 10.3390/nu15020325","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Plasma and urine UHPLC-MS/MS","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4cee3562-b358-5af3-8634-fd46d4e1755c","evidence_kind":"source_excerpt","locator":"Lines 33-42","start_line":33,"end_line":42,"excerpt":"## hydroxytyrosol-supplement-metabolites\nAfter single olive-derived supplement doses, homovanillic acid, hydroxytyrosol-3-O-sulfate and DOPAC were major plasma and urine metabolites, with plasma peaks at about 30 minutes.\nModel/species: Twelve healthy volunteers in a randomized blinded crossover study\nTissue/system: Plasma and urine UHPLC-MS/MS\nExposure: 30.58 or 61.48 mg hydroxytyrosol supplement; fortified olive-oil control\nRoute: Oral\nDuration: 0.5-12 hours\nLimits: Higher bioavailability is a prerequisite, not proof of cardiovascular protection.\nPrimary reference: Oral Bioavailability and Metabolism of Hydroxytyrosol from Food Supplements. (2023). https://pubmed.ncbi.nlm.nih.gov/36678196/ DOI: 10.3390/nu15020325\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Twelve healthy volunteers in a randomized blinded crossover study","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f83cd982-34f0-55d4-8563-eedfb0f009f2","stable_key":"import-cb41aa31-e26b-5b60-b7e0-e4985fb7aea8","title":"Hydroxytyrosol: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"7677fedffc16af238fc1ace3f88d206dd42b29b163c40b6e69ba6ed2457a3aee","revision_id":"1e0bd617-6834-5a2d-a74e-c058967d99b7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}