{"id":"7f1a1685-ec0a-5310-81d3-9c5c91f9bc0a","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-becker-ldl","predicate":"reduces_tested","statement":"In 62 statin-intolerant participants, the studied red yeast rice regimen reduced LDL by 43 mg/dL at 12 weeks and 35 mg/dL at 24 weeks, versus 11 and 15 mg/dL with placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"77a211ca-a061-5bde-95f2-d7291672151f","mechanism_event_label":"This particular preparation lowered LDL in a randomized trial.","subject":{"id":"0fb5e8c6-6cfc-514e-aaf5-a2eb3f8a0b23","slug":"ryr-becker-2009-preparation","display_name":"Red yeast rice preparation in the Becker 2009 trial","entity_type_key":"chemical_species"},"object":{"id":"ac5f5914-4824-5f9b-93c7-a6b5a52b53af","slug":"ldl-cholesterol-concentration","display_name":"LDL cholesterol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"77a211ca-a061-5bde-95f2-d7291672151f","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-becker-ldl-event","event_type":"observed_relationship","label":"This particular preparation lowered LDL in a randomized trial.","description":"In 62 statin-intolerant participants, the studied red yeast rice regimen reduced LDL by 43 mg/dL at 12 weeks and 35 mg/dL at 24 weeks, versus 11 and 15 mg/dL with placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0fb5e8c6-6cfc-514e-aaf5-a2eb3f8a0b23","slug":"ryr-becker-2009-preparation","display_name":"Red yeast rice preparation in the Becker 2009 trial","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ac5f5914-4824-5f9b-93c7-a6b5a52b53af","slug":"ldl-cholesterol-concentration","display_name":"LDL cholesterol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"1,800 mg twice daily for 24 weeks; both groups also entered a lifestyle program.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small selected population; formulation-specific lipid result, not proof of cardiovascular-event reduction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"This particular preparation lowered LDL in a randomized trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[19528562] Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19528562/ · DOI 10.7326/0003-4819-150-12-200906160-00006","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"916996bd-d4ca-59cf-87a0-e750ba4e6964","evidence_kind":"source_excerpt","locator":"Lines 340-346","start_line":340,"end_line":346,"excerpt":"## red-yeast-rice-becker-ldl\nThis particular preparation lowered LDL in a randomized trial.\nIn 62 statin-intolerant participants, the studied red yeast rice regimen reduced LDL by 43 mg/dL at 12 weeks and 35 mg/dL at 24 weeks, versus 11 and 15 mg/dL with placebo.\nModel: 1,800 mg twice daily for 24 weeks; both groups also entered a lifestyle program.\nLimitations: Small selected population; formulation-specific lipid result, not proof of cardiovascular-event reduction.\nEvidence access: Primary abstract\n[19528562] Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19528562/ · DOI 10.7326/0003-4819-150-12-200906160-00006","model_system":"1,800 mg twice daily for 24 weeks; both groups also entered a lifestyle program.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"271bbcecaaacc76ad4d06718ae592dc6a1b33e3e459adfdd36cbd0ac5f09c0f6","revision_id":"9c30956c-206c-5c49-ae42-81b070088e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}